The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier [PDF]
Biomolecules, 2020 Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC).
Benoît Maillot +3 more
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The relationships between transketolase, yeast pyruvate decarboxylase and pyruvate dehydrogenase of the pyruvate dehydrogenase complex [PDF]
FEBS Letters, 1993 The amino acid sequences of four thiamine pyrophosphate‐requiring enzymes were aligned with the published amino acid sequence of the transketolase of Hansenula polymorpha. Sequences of the combined α and β subunits of the E1 enzyme of the pyruvate dehydrogenase complexes of Homo sapiens and Bacillus stearothermophilus aligned well with the ...
Brian H. Robinson, Kathy Chun
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Pyruvate Substitutions on Glycoconjugates [PDF]
International Journal of Molecular Sciences, 2019 Glycoconjugates are the most diverse biomolecules of life. Mostly located at the cell surface, they translate into cell-specific “barcodes” and offer a vast repertoire of functions, including support of cellular physiology, lifestyle, and pathogenicity.
Fiona F. Hager +4 more
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Pyruvate kinase phosphatase [PDF]
FEBS Letters, 1981 1. Introduction Liver pyruvate kinase can be phosphorylated and simultaneously inactivated by CAMP-dependent pro- tein kinase; the inactivated enzyme can be reactivated by a multifunctional protein phosphatase (review [ 13). The inactivation of pyruvate kinase has been observed in isolated hepatocytes incubated in the presence of glucagon and in this ...
Mary-Frances Jett +2 more
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The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles? [PDF]
Islets, 2011 Pyruvate is the major product of glycolysis in pancreatic β-cells, and its ultimate metabolic fate depends on the relative activities of two enzymes. The first, pyruvate carboxylase (PC) replenishes oxaloacetate withdrawn from the tricarboxylic acid (TCA) cycle via the carboxylation of pyruvate to form oxaloacetate.
Mary C. Sugden, Mark J. Holness
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Effect of dexamethasone on gluconeogenesis, pyruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes [PDF]
Biochemical Journal, 1993 Treatment of 18 h-starved rats with dexamethasone and subsequent isolation and incubation of the hepatocytes in the presence of the steroid increased gluconeogenic flux with both 1.0 mM pyruvate and 1.0 mM lactate plus 0.2 mM pyruvate as the substrate. The magnitude of stimulation was comparable with both substrates.
Claire G. Jones +2 more
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MECHANISM OF FORMATION OF OXALOACETATE AND PHOSPHOENOL PYRUVATE FROM PYRUVATE
THE JOURNAL OF VITAMINOLOGY, 1968 The pathways by which pyruvate, oxaloa cetate and P-enolpyruvate are interlinked have been reviewed. The enzymes involved (see Table 1) and pathways differ markedly in different cells. Animals and yeast possessing pyruvate carboxylase are able to convert pyruvate to oxaloacetate directly by CO2 fixation, but the propionic acid bacteria and E.
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Transaminations with pyruvate and other α-keto acids [PDF]
, 1956 E V Rowsell
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Specificity of pyruvate kinase [PDF]
Biochimica et Biophysica Acta, 1959 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32459/1/0000543 ...
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RELATIONSHIPS OF PYRUVATE AND LACTATE DURING ANAEROBIC METABOLISM. I. EFFECTS OF INFUSION OF PYRUVATE OR GLUCOSE AND OF HYPERVENTILATION1 [PDF]
, 1958 William E. Huckabee
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