Results 21 to 30 of about 24,261 (292)

Development of Catalytic Asymmetric Reactions of Pyruvates as Nucleophiles [PDF]

Okinawa Institute of Science and Technology Graduate UniversityDoctor of PhilosophyPyruvates or α-ketoesters, are important molecules in both organic chemistry and biology due to their intrinsic reactivity. Pyruvates can act as nucleophiles (reactions as
Mondal, Santanu
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Complications neurologiques de la carence en thiamine (Vitamine B1) : A propos d’un cas avec revue de la litterature [PDF]

, 2021
Introduction: La carence en thiamine peut se manifester par deux formes cliniques : une forme cardiaque nommée béribéri humide, et une forme neurologique qui est le béribéri sec ; cette dernière peut se traduire cliniquement par une neuropathie ...
Doghmi , Kamal, El Haddad, Mariyam, El Maaroufi, Hicham, Jennane, Selim, Loubnan , Sarah, Mahtat, El Mehdi, Mikdame, Mohamed   +6 more
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Kohn-Sham formalizmustól eltérő (hatványsoros) sűrűség funkcionál algoritmus kidolgozása kémiai potenciálfelületek vizsgálatára. = Non Kohn-Sham formalism density functional algorithm (using power series) for calculating chemical potential energy surfaces. [PDF]

, 2010
A sűrűség funkcionálok (DFT) részletes analízisét végeztem. Ebben a több-elektron sűrűség tulajdonságait és viselkedését analizáltam a két Hohenberg-Kohn (HK) tétel tekintetében.
Kristyán, Sándor
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Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Asymmetric transformations involving 1,2-diarbonyl compounds as pronucleophiles

, 2012
International audienceThis article concentrates on the versatile nucleophilic reactivity of 1,2-dicarbonyl compounds in various asymmetric transformations. Although underexploited in comparison to their 1,3-dicarbonyl homologues, the presence of adjacent
Bonne, Damien, Raimondi, Wilfried, Rodriguez, Jean   +2 more
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Prebiotic synthesis of phosphoenol pyruvate by α-phosphorylation-controlled triose glycolysis [PDF]

, 2017
Phosphoenol pyruvate is the highest-energy phosphate found in living organisms and is one of the most versatile molecules in metabolism. Consequently, it is an essential intermediate in a wide variety of biochemical pathways, including carbon fixation ...
A Eschenmoser, A Eschenmoser, A Eschenmoser, A Weber, AD Anbar, AD Keefe, AD Keefe, AD Keefe, Adam J. Coggins, AI Oparin, BH Patel, BM Tebo, BS Bal, C Chatgilialoglu, C De Duve, C Huber, CT Walsh, D Muller, D Trail, DL Nelson, EJ Corey, FR Bowler, G Cooper, GD Cody, H Jeong, HJ Morowitz, J Halperin, J Rabinowitz, JB Maynard, JD Sutherland, JE Post, JF Kasting, JG Forsythe, KI Öberg, LA Leshin, LB Mullen, LE Orgel, LE Orgel, MA Keller, MA Pasek, Matthew W. Powner, MI Guzman, MW Powner, MW Powner, N Goldman, PS Braterman, R Hazen, R Krishnamurthy, R Krishnamurthy, R Liu, R Osterberg, R Pascal, R Saffhill, RL Rudnick, RM Hazen, RW Nargoski, S Potter, S Solomon, SL Miller, SO Nwaukwa, V Kolb, VN Sagi, WA Jackson, XV Zhang, YS Kim   +64 more
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The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Palladium-catalysed enolate arylation in the synthesis of aromatic heterocycles and substituted heterocycles [PDF]

, 2017
Chapter 1. Introduction A literature background on the early development of the Pd-catalysed cross-coupling reactions and the later discovery of the enolate arylation reaction is presented.
Esteves, Carlos Henrique Alves
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