Neutrophil extracellular traps and phagocytosis in Pythium insidiosum. [PDF]
PLoS One, 2023 Neutrophils are innate immune cells that play crucial roles in response to extracellular pathogens, including bacteria and fungi. Pythium insidiosum (P insidiosum) is a fungus-like pathogen that causes "pythiosis" in mammals.
Sriwarom A +4 more
europepmc +6 more sources
Ex vivo observation of Pythium insidiosum-antigen treated neutrophils on three Pythium insidiosum strains isolated from vascular pythiosis patients. [PDF]
Hum Vaccin ImmunotherThe mechanisms of Pythium insidiosum-antigen (PIA) immunotherapy activating a patient’s immune system are unknown. We evaluated the interleukin-8 (IL-8) serum levels during P.
Medhasi S +6 more
europepmc +5 more sources
Commentary: Pythium insidiosum keratitis
Indian Journal of Ophthalmology, 2019 Prashant Garg
doaj +4 more sources
Activity Against Pythium insidiosum and Isolated Constituents of Cordia insignis Roots. [PDF]
Chem BiodiversPythiosis, caused by the oomycete Pythium insidiosum, is a worrying disease with its challenging treatment due to the phylogeny of the pathogen. Natural products are a promising alternative in the treatment of diseases.
de Oliveira RC +8 more
europepmc +2 more sources
Immune Camouflage in <i>Pythium insidiosum</i> Keratitis: A Hypothesis on Molecular Mimicry and Host Pattern Recognition Receptor Evasion. [PDF]
Clin OphthalmolPythium insidiosum keratitis is a vision-threatening corneal infection that often mimics fungal keratitis, yet it responds poorly to standard antifungals. Historically, approximately 80% of cases have required surgical excision of the cornea.
Gurnani B, Kaur K.
europepmc +2 more sources
Renaissance of an Emerging Pathogen-<i>Pythium insidiosum</i> Keratitis: An Indian Perspective. [PDF]
Clin OphthalmolPythium insidiosum keratitis is an aggressive, vision-threatening corneal infection increasingly recognized across India, particularly among agricultural workers during monsoon season.
Gurnani B, Kaur K.
europepmc +2 more sources
Understanding barriers, recommended solutions, and future prospects for the diagnosis and management of Pythium insidiosum keratitis. [PDF]
Indian J Ophthalmol, 2023 Pythium insidiosum keratitis (PIK) is a devastating corneal infection resulting in blindness in a large number of cases. Clinically and morphologically, it closely mimics fungal keratitis, and hence is also labeled as “parafungus.” Although many clinical
Gurnani B, Kaur K.
europepmc +2 more sources
Worldwide distribution of human pythosis and biological characteristics of a <i>Pythium insidiosum</i> strain susceptible to antibiotics from China: a dual-scale study. [PDF]
Front Med (Lausanne)Introduction Pythiosis, caused by Pythium insidiosum (P. insidiosum), is an emerging disease with high mortality and morbidity. Despite its clinical severity and geographical strain variations, diagnostic and treatment challenges persist.
Liu X +14 more
europepmc +2 more sources
Nucleic Acid-Based Detection of Pythium insidiosum: A Systematic Review. [PDF]
J Fungi (Basel), 2022 Pythiosis, a life-threatening infectious condition caused by Pythium insidiosum, has been increasingly reported in humans and animals worldwide. Antifungal drugs usually fail to control the pathogen.
Sridapan T, Krajaejun T.
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Outcomes of therapeutic penetrating keratoplasty in <i>Pythium insidiosum</i> keratitis managed with a combination of antibiotics. [PDF]
Indian J Ophthalmol, 2023 Purpose: To describe the clinical outcomes of therapeutic penetrating keratoplasty (TPK) in patients with Pythium insidiosum keratitis following treatment with anti-pythium therapy (APT) consisting of linezolid and azithromycin.
Kate A +6 more
europepmc +2 more sources