Results 61 to 70 of about 6,424,880 (277)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
q-Differential equations for q-classical polynomials and q-Jacobi-Stirling numbers [PDF]
, 2016 We introduce, characterise and provide a combinatorial interpretation for the so-called q-Jacobi–Stirling numbers. This study is motivated by their key role in the (reciprocal) expansion of any power of a second order q-differential operator having the
Zeng, Jiang +5 more
core +1 more source
Uncertainty and Tobin´s q in a monopolistic competition framework [PDF]
, 1991 This paper combines the adjustment cost hypothesis of Tobin's q models with Malinvaud's proposition that demand uncertainty matters in explaining investment.
Licandro, Omar
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Evolution of dipolar mixed-mode coupling factor in red giant stars: impact of buoyancy spike
, 2022 Mixed modes observed in red giants allow for investigation of the stellar interior structures. One important feature in these structures is the buoyancy spike caused by the discontinuity of the chemical gradient left behind during the first dredge-up ...
Gizon, Laurent +11 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Q-factor mediated quasi-BIC resonances coupling in asymmetric dimer lattices
, 2022 Resonance coupling in the regime of bound states in the continuum (BICs) provides an efficient method for engineering nanostructure's optical response with various lineshape while maintaining an ultra-narrow linewidth feature, where the quality factor of
Lei Xu (78676) +2 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Impedance analyzer for trademarks of aqueous-alcoholic drinks identification
Технологія та конструювання в електронній апаратурі, 2012 The article shows a possibility of determining the type of aqueous-alcoholic drink, based on measurements and analysis of the frequency characteristics of active and reactive impedance components of the solution in the frequency range 0,5–105 Hz.
A. L. Kukla +3 more
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