Results 41 to 50 of about 207,646 (257)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Study of 14N(γ,np)3α Reaction for Eγ up to 150 MeV

open access: yesEast European Journal of Physics, 2022
The reaction 14N(g,np)3a induced by bremsstrahlung photons of endpoint energy Egmax = 150 MeV has been investigated using diffusion chamber, which is placed into the magnetic field.
Serhii Afanasiev
doaj   +1 more source

A New Method for Derivation of Statistical Weight of the Gentile Statistics

open access: yes, 2015
We present a new method for obtaining the statistical weight of the Gentile Statistics. In a recent paper, Perez and Tun presented an ap- proximate combinatoric and an exact recursive formula for the statistical weight of Gentile Statistics, beginning ...
Selvi, Sevilay, Uncu, Haydar
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Relationships between Near-Surface Horizontal Dust Fluxes and Dust Depositions at the Centre and Edge of the Taklamakan Desert

open access: yesLand, 2022
The emission, transport, and deposition of dust are frequently the focus of dust aerosol studies. However, owing to limited observation data, few studies have examined the relationships between the key parameters of dust transport, especially in typical ...
Wen Huo   +9 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Airborne observations of newly formed boundary layer aerosol particles under cloudy conditions [PDF]

open access: yesAtmospheric Chemistry and Physics, 2018
This study describes the appearance of ultrafine boundary layer aerosol particles under classical non-favourable conditions at the research site of TROPOS (Leibniz Institute for Tropospheric Research).
B. Altstädter   +11 more
doaj   +1 more source

Combinatorial interpretation of Haldane-Wu fractional exclusion statistics

open access: yes, 2002
Assuming that the maximal allowed number of identical particles in state is an integer parameter, q, we derive the statistical weight and analyze the associated equation which defines the statistical distribution.
A. K. Aringazin   +8 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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