Results 61 to 70 of about 1,793,420 (289)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

On the Q-phase of carbonaceous chondrites

open access: yes, 1999
One of the unresolved puzzles of meteoritics is the nature of the carrier of the so-called heavy planetary gases. Apparently, these gases reside mainly in a minor fraction, which has been dubbed Q by Lewis et al. in analogy of the naming by Papanastasiou
Heymann, D., Vis, R.D.
core   +1 more source

Q-space analysis of scattering by particles: a review [PDF]

open access: yes, 2013
This review describes and demonstrates the Q-space analysis of light scattering by particles. This analysis involves plotting the scattered intensity versus the scattering wave vector q = (4π/λ) sin(θ/2) on a double log plot.
Sorensen, Christopher M.
core   +1 more source

Stealth multiboson signals

open access: yesEuropean Physical Journal C: Particles and Fields, 2017
We introduce the ‘stealth bosons’ S, light boosted particles with a decay $$S \rightarrow AA \rightarrow q \bar{q} q \bar{q}$$ S→AA→qq¯qq¯ into two daughter bosons A, which subsequently decay into four quarks that are reconstructed as a single fat jet ...
J. A. Aguilar-Saavedra
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Light scattering Q-space analysis of irregularly shaped particles [PDF]

open access: yes, 2016
Citation: Heinson, Y. W., Maughan, J. B., Heinson, W. R., Chakrabarti, A., & Sorensen, C. M. (2016). Light scattering Q-space analysis of irregularly shaped particles. Journal of Geophysical Research-Atmospheres, 121(2), 682-691.
Maughan, Justin B.   +9 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Sentential Word Order and the Syntax of Question Particles [PDF]

open access: yes, 2010
Polar question particles in languages with VO word order pose a problem for the otherwise robust Final-Over-Final Constraint, which rules out a head-final phrase immediately dominating a head-initial phrase (Holmberg 2000).
Bailey, Laura R.
core  

Study of lead phytoavailability for atmospheric industrial micronic and sub-micronic particles in relation with lead speciation [PDF]

open access: yes, 2009
Particles from channelled emissions of a battery recycling facility were size-segregated and investigated to correlate their speciation and morphology with their transfer towards lettuce. Microculture experiments carried out with various calcareous soils
Sobanska, Sophie   +4 more
core   +1 more source

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