Results 41 to 50 of about 1,187,227 (316)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Finite-Time Analysis of Asynchronous Q-Learning Under Diminishing Step-Size From Control-Theoretic View

IEEE Access
Q-learning has long been one of the most popular reinforcement learning algorithms, and theoretical analysis of Q-learning has been an active research topic for decades.
Han-Dong Lim, Donghwan Lee
doaj   +1 more source

Implementation of Islanding Recognizing Technique for Wind Distributed Generations Considering Insignificant NDZ

Frontiers in Energy Research, 2022
The incorporation of distributed energy resources (DERs) into the electricity grid yields environmental, technical, and economic benefits. However, in addition to the benefits, the widespread use of DERs causes technical issues.
Safdar Raza, Hafiz Mudassir Munir, Nouman Shafique, Wajiha Amjad, Mohit Bajaj, Mamdouh L. Alghaythi   +5 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Scalable Hybrid Switching-Driven Software Defined Networking Issue: From the Perspective of Reinforcement Learning Standpoint

IEEE Access
The Software-Defined Networking technology promises to enhance network performance and cost reduction for service providers by providing scalability, flexibility, and programmability through the separation of the control plane from the data plane ...
Max Blose, Lateef Adesola Akinyemi, Stephen Ojo, Muhammad Faheem, Agbotiname Lucky Imoize, Arfat Ahmad Khan   +5 more
doaj   +1 more source

Robust (Q,S,R)-γ-Dissipative and H₂ Performances for Switched Systems with Mixed Time Delays

Mathematics, 2023
This paper investigates the switching on switching rule and sampling input to guarantee (Q,S,R)-γ-dissipative and H2 performances for switched systems with mixed time delays.
Ker-Wei Yu, Chang-Hua Lien, Hao-Chin Chang, Cheung-Chieh Ku, Sundarapandian Vaidyanathan, Cheng-Ruei Yu, Hung-Chih Li, Yi-You Hou   +7 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

PULSED KGd(WO4)2 RAMAN LASER: TOWARDS EMISSION LINEWIDTH NARROWING

Приборы и методы измерений, 2015
The linewidth of a KGd(WO4)2 pulsed Raman laser is analysed experimentally for different configurations of the Raman and pump resonators: with narrow and broadband pump emission profiles, with and without linewidth narrowing elements in the Raman laser ...
V. G. Savitski
doaj  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Diode-pumped Alexandrite lasers in Q-switched and cavity-dumped Q-switched operation

Optics Express, 2016
We present the first study of Q-switched Alexandrite lasers under continuous-wave diode-pumping with operation up to 10 kHz repetition rates in TEM00, with spatial quality M2 1.15. With a pulsed-diode dual-end-pumped design, pulse energy is scaled to a record level of 3 mJ.
Thomas, GM, Minassian, A, Sheng, X, Damzen, MJ   +3 more
openaire   +3 more sources