Results 111 to 120 of about 48,801 (303)

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

i(8)(q10) in ALL [PDF]

, 2018
Isochromosomes are nonrandom chromosomal anomalies in acute lymphoblastic leukemia (ALL), but relatively few patients ALL and i(8)(q10) have been reported.
Zamecnikova, Adriana
core   +1 more source

Customized three dimensionally printed palatal stents: A randomized controlled clinical trial

Clinical Advances in Periodontics, EarlyView.
Abstract Background Soft tissue grafts are commonly used in periodontal surgery around teeth and implants. However, few studies have examined donor‐site pain through patient‐reported outcomes following soft tissue grafting. This study aimed to minimize donor‐site pain during autologous gingival grafting using a three‐dimensionally (3D)‐printed stent ...
Mi‐Seon Goh, Seong‐Min Kim, Hyung‐Keun You, Jong‐Chan Choi, Dong‐Woon Lee   +4 more
wiley   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, EarlyView.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

Coenzyme q10 therapy.

Molecular syndromology, 2014
This work was supported by grants (FIS PI10/00543, FIS EC08/00076) from the Ministerio de Sanidad, Spain, and Fondo Europeo de Desarrollo Regional (FEDER-Unión Europea); Servicio Andaluz de Salud-Junta de Andalucía (SAS 111242); Proyecto de Investigación de Excelencia de la Junta de Andalucía (CTS-5725); and by AEPMI (Asociación de Enfermos de ...
Garrido-Maraver, Juan, Cordero, Mario D., Oropesa-Ávila, Manuel, Fernández-Vega, Alejandro, Mata, Mario de la, Delgado Pavón, Ana, Miguel, Manuel de, Pérez Calero, Carmen, Villanueva Paz, Marina, Cotán, David, Sánchez-Alcázar, José Antonio   +10 more
openaire   +2 more sources

Coenzyme Q10 effects in neurodegenerative disease

, 2009
Meredith Spindler1, M Flint Beal1,2, Claire Henchcliffe1,21Department of Neurology, 2Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USAAbstract: Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial ...
Claire Henchcliffe, Meredith Spindler, M Flint Beal   +2 more
core  

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Does ESG Performance Reduce Default Risk in Insurance Firms? Evidence From Life and Non‐Life Sectors

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines whether environmental, social, and governance performance is associated with lower default risk in European insurance firms, and whether the strength of this association differs between life and non‐life business models.
S. Miani, M. Mantovani, E. Palmieri
wiley   +1 more source

Reversal of statin-induced memory dysfunction by co-enzyme Q10: a case report

, 2015
Basil N Okeahialam Cardiology Sub-Unit 1, Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria Abstract: Statins are useful in the armamentarium of the clinician dealing with dyslipidemia, which increases cardiovascular morbi-mortality
Okeahialam BN
core  

What Drives CSR Performance: Structures, Declarations or Values?

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Sustainability and corporate social responsibility (CSR) are increasingly central to strategic management, yet a gap persists between formal commitments and actual practice. The study explores the structural and value‐based predictors of the institutional integration of CSR and sustainability, with a focus on the mediating role of the CSR ...
Pavla Vrabcová, Lukáš Falát, Hana Urbancová, Peter Madzík   +3 more
wiley   +1 more source