Results 11 to 20 of about 165,025 (335)
Bioactive Materials, 2023 Stem cell transplantation has been proved a promising therapeutic instrument in intervertebral disc degeneration (IVDD). However, the elevation of oxidative stress in the degenerated region impairs the efficiency of mesenchymal stem cells (BMSCs ...
Junyuan Sun +9 more
doaj +2 more sources
Metabolic Targets of Coenzyme Q10 in Mitochondria
Antioxidants, 2021 Coenzyme Q10 (CoQ10) is classically viewed as an important endogenous antioxidant and key component of the mitochondrial respiratory chain. For this second function, CoQ molecules seem to be dynamically segmented in a pool attached and engulfed by the ...
Agustín Hidalgo-Gutiérrez +6 more
semanticscholar +1 more source
Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)
Antioxidants, 2021 The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q10’s role in health and disease.
Ilenia Cirilli +8 more
semanticscholar +1 more source
Coenzyme Q10 Analogues: Benefits and Challenges for Therapeutics
Antioxidants, 2021 Coenzyme Q10 (CoQ10 or ubiquinone) is a mobile proton and electron carrier of the mitochondrial respiratory chain with antioxidant properties widely used as an antiaging health supplement and to relieve the symptoms of many pathological conditions ...
J. M. Suárez-Rivero +8 more
semanticscholar +1 more source
Coenzyme Q10 supplementation - in ageing and disease.
Mechanisms of Ageing and Development, 2021 Coenzyme Q10 (CoQ10) is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells produce CoQ10 by a specialized cytoplasmatic-mitochondrial pathway. CoQ10 deficiency
J. Aaseth, J. Alexander, U. Alehagen
semanticscholar +1 more source
Nutrix Journal, 2022 Background Metabolic syndrome (MetS) as a cluster of conditions including hyperlipidemia, hypertension, hyperglycemia, insulin resistance, and abdominal obesity is linked to cardiovascular diseases and type 2 diabetes.
Abbas Ali Sangouni +4 more
semanticscholar +1 more source
Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges.
Comprehensive Reviews in Food Science and Food Safety, 2020 World population growth and aging are posing unprecedented challenges in sustaining the health of 9.1 billion people that will be occupying the planet by 2050.
Marta Arenas-Jal +2 more
semanticscholar +1 more source
Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases
Nutrients, 2021 Coenzyme Q10 (CoQ10) is an essential cofactor in oxidative phosphorylation (OXPHOS), present in mitochondria and cell membranes in reduced and oxidized forms.
L. Testai +4 more
semanticscholar +1 more source
Disorders of Human Coenzyme Q10 Metabolism: An Overview
International Journal of Molecular Sciences, 2020 Coenzyme Q10 (CoQ10) has a number of vital functions in all cells, both mitochondrial and extramitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation, CoQ10 serves as a lipid soluble antioxidant, plays an important role in ...
I. Hargreaves, R. Heaton, D. Mantle
semanticscholar +1 more source
Coenzyme Q10, oxidative stress, and male infertility: A review
Clinical and Experimental Reproductive Medicine, 2021 Male infertility has a complex etiopathology, which mostly remains elusive. Although research has claimed that oxidative stress (OS) is the most likely underlying mechanism of idiopathic male infertility, the specific treatment of OS-mediated male ...
A. Alahmar +5 more
semanticscholar +1 more source