Results 201 to 210 of about 48,801 (303)

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Reengineering statin therapy to protect skeletal muscle: nanocarrier strategies for mitigating mitochondrial dysfunction and myotoxicity. [PDF]

Inflamm Regen
Alabrahim OAA, Allam NK.
europepmc   +1 more source

Expanding Spectrum of FIG4‐Related Neurological Disorders of Lysosomal Homeostasis: Case Report and Overview of the Potential Genotype–Phenotype Correlations

Clinical Genetics, EarlyView.
FIG4 is essential for lysosomal homeostasis. FIG4‐related disorders present as a continuous spectrum from the juvenile lethality in Yunis‐Varon syndrome to an increased risk of amyotrophic lateral sclerosis (ALS) in adult life. FIG4‐related disorders comprise a novel group of disorders of lysosomal homeostasis and can be classified into severe ...
Pankaj Prasun, Matthew Rasberry
wiley   +1 more source

Cholesterol-driven mitochondrial rejuvenation by quercetin nanotherapeutics restores implant osseointegration in diabetes. [PDF]

Bioact Mater
Wei J, Chen R, Zhang X, Ding X, Huang Z, Lv X, Zhang Y, Jiang X, Yang Y, Dai M, Wei X, Lai H, Shi J.   +12 more
europepmc   +1 more source

Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy

Clinical Genetics, EarlyView.
Opticus atrophy—Genetic testing with WES/WGS in 62 patients with optic atrophy provided a genetic diagnosis in 21 patients (33.9%). 42.9% of these involved non‐OPA1 genes, including WFS1, ACO2, NR2F1, UCHL1, CACNA1F, and COQ2, where the genetic diagnosis prompted additional clinical evaluation, surveillance, or therapeutic intervention.
Katrine M. Johannesen, Karen Grønskov, Line Kessel, Sarah Linea von Holstein, Lisbeth Birk Møller, Mette Kjøbæk Gundestrup Andersen, Marianne Søndergaard Khinchi, Steffen Hamann, Marianne Wegener, Mette Bertelsen   +9 more
wiley   +1 more source

Nationwide survey of Japanese Physicians on Kampo medicine use in frailty care. [PDF]

Sci Rep
Hosoi T, Yakabe M, Kase Y, Miyawaki M, Hashimoto S, Matsumoto S, Yunoki M, Kondo S, Ishii M, Ogawa S.   +9 more
europepmc   +1 more source

A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells

Cell Proliferation, EarlyView.
This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang, Bo Deng, Nini Guo, Yiyi Ding, Zhangjingwen Xu, Yiwen Lu, Yue Ma, Qian Ren, Nan Wang, Pengyu Huang, Xiaotong Ma   +10 more
wiley   +1 more source

The combined effects of temperature and salinity on the stomatogastric nervous system of two species of decapod crustacea. [PDF]

J Neurophysiol
Carrier KL, Romano N, Scaria LK, Palmer M, O'Leary RM, Marder E, Powell DJ.   +6 more
europepmc   +1 more source

Association between gestational diabetes, ethnicity and migrant length of residence: An Australian cohort study

Diabetic Medicine, EarlyView.
Abstract Aims Investigate the relationship of gestational diabetes (GDM) risk for specific migrant groups compared to the Australian born of each ethnic group and length of residence (LOR) in Australia. Methods Retrospective observational cohort study from June 2020 to November 2023 at 10 Australian hospitals.
Sheila Pham, Helena Qian, James Elhindi, Olivia Byrnes, Michelle de Vroome, Geraldine Gilroy, Tanya Nippita, Gayatri Talla, Lisa White, Dipti Zachariah, N. Wah Cheung, Dharmintra Pasupathy, Sarah J. Melov   +12 more
wiley   +1 more source

Anti-Inflammatory and Neuroprotective Effects of a Novel Water-Soluble Formulation of Coenzyme-Q10 and Ashwagandha Root Extract in a Paraquat-Induced Rat Model of Parkinson's Disease. [PDF]

Biomed Hub
Vegh C, Walach G, Dube K, Malakoti-Negad NJ, Wear D, Jayawardena H, Patel M, Polsinelli A, Eren S, Cohen J, Pandey S.   +10 more
europepmc   +1 more source