Results 31 to 40 of about 743 (146)

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

Advanced Science, Volume 12, Issue 34, September 11, 2025.
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn, Julian O. Streit, Christopher A. Waudby, Tomasz Włodarski, Angelo Miguel Figueiredo, John Christodoulou, Janet R. Kumita   +6 more
wiley   +1 more source

Concerns regarding the sustainable development of energy – opportunities and challenges for RES adoption in Poland

International Journal of Management and Economics
Energy transition is a time- and capital-intensive process, particularly in the shift from fossil fuels to renewable energy sources (RES). Poland exemplifies this transition, navigating fluctuations in energy prices. The invasion of Ukraine by Russia has
Przedworska Kornelia, Hadasik Bartłomiej, Krawczyńska Dominika, Ryczko Aleksandra, Kubiczek Jakub   +4 more
doaj   +1 more source

Intramolecular epistasis correlates with divergence of specificity in promiscuous and bifunctional NSAR/OSBS enzymes

Protein Science, Volume 34, Issue 5, May 2025.
Abstract Understanding the functions and evolution of specificity‐determining residues is essential for improving strategies to predict and design enzyme functions. Whether the function of an amino acid residue is retained during evolution depends on intramolecular epistasis, which occurs when the same residue contributes to different phenotypes in ...
Dat P. Truong, Roopa Dharmatti, Dylan Suriadinata, Jamison Huddleston, Rebecca Skouby, Gladys Owusu Addo, Mingzhao Zhu, Anjana Delpe Acharige, Reethu Sankari Bayana, Cristian Davila, Susan C. Fults, Frank M. Raushel, Kenneth G. Hull, Daniel Romo, Margaret E. Glasner   +14 more
wiley   +1 more source

Quantification of the impact of innovations in industry and infrastructure for sustainable circular economy production and consumption

Journal of Innovation & Knowledge
The primary aim of this study was to quantify the impact of industry and infrastructure innovations on sustainable production and consumption within the circular economy (CE) in European Union (EU) countries.
Marinko Skare, Beata Gavurova, Martin Rigelsky   +2 more
doaj   +1 more source

Identification and study of new NF‐κB‐inducing kinase ligands derived from the imidazolone scaffold

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
A new family of NF‐κB‐inducing kinase (NIK) ligands bearing an imidazolone moiety were synthesized. The best compound showed a dose‐dependent inhibition of p100 to p50 processing in cellular assays, a key step in nuclear factor κB (NF‐κB) activation. Based on computational techniques, a plausible binding mode is proposed.
Francisco Maqueda‐Zelaya, Lara Valiño‐Rivas, Ana Milián, Sara Gutiérrez, José Luis Aceña, Javier Garcia‐Marin, Mª Dolores Sánchez‐Niño, Juan J. Vaquero, Alberto Ortiz   +8 more
wiley   +1 more source

Beyond Sunlight: How Co2 Emissions, Coal Lock-in, and Global Finance Shape Australia’s Solar Energy Consumption - An ARDL Analysis with Robustness Checks

ECONOMICS
This study examines the determinants of solar energy adoption in Australia between 1991 and 2023 using an Autoregressive Distributed Lag (ARDL) model. The results reveal long-run equilibrium relationships and short-run adjustment mechanisms between solar
Hechmi Soumaya
doaj   +1 more source

A pain research strategy for Europe: A European survey and position paper of the European Pain Federation EFIC

European Journal of Pain, Volume 29, Issue 1, January 2025.
Abstract Background Pain is the leading cause of disability and reduced quality of life worldwide. Despite the increasing burden for patients and healthcare systems, pain research remains underfunded and under focused. Having stakeholders identify and prioritize areas that need urgent attention in the field will help focus funding topics, reduce ...
Gisèle Pickering, Mary O'Keeffe, Kirsty Bannister, Susanne Becker, Sonia Cottom, Felicia J. Cox, Elon Eisenberg, David P. Finn, Patrice Forget, Thomas Graven‐Nielsen, Eija Kalso, Magdalena Kocot‐Kepska, Hugo Leite‐Almeida, Jose Antonio Lopez‐Garcia, Mira Meeus, André Mouraux, Bruno Pereira, Livia Puljak, Michiel F. Reneman, Iben Rohde, Ioannis Sotiropoulos, Nathan Skidmore, Thomas R. Tölle, Snezana Tomasevic Todorovic, Andrea Truini, Kevin E. Vowles, Esther Pogatzki‐Zahn, Luis Garcia‐Larrea, Brona M. Fullen   +28 more
wiley   +1 more source

Climate policy uncertainty and environmental degradation: Does democracy moderate this relationship?

Cleaner Environmental Systems
This study investigates the impact of climate policy uncertainty on environmental degradation and examines the moderating role of democracy in this relationship. Utilizing annual data from 126 economies spanning the years 1996–2021, and employing dynamic
Antonios Persakis, Ioannis Tsakalos, Vasileios Gkonis, Michail Nerantzidis   +3 more
doaj   +1 more source

Measuring an audit quality climate among employees

International Journal of Auditing, Volume 29, Issue 1, Page 1-33, January 2025.
The International Standard on Quality Management requires, among other things, that audit firm leadership promotes a quality‐oriented culture in firms. We add a novel contribution to the audit quality literature by developing an instrument to measure the audit quality climate in audit firms.
Johanna Alida Kritzinger, Karin Barac
wiley   +1 more source

Real‐life users of hormonal or thermal male contraception: An analysis of female partners’ motivation, experience, and satisfaction

Andrology, Volume 12, Issue 8, Page 1808-1821, November 2024.
Abstract Background Two male contraceptive methods that inhibit spermatogenesis currently exist: thermal male contraception and hormonal male contraception. Only five studies have been conducted on the acceptability of these methods among men; among women, only the hypothetical acceptability of such a male contraceptive approach as the sole ...
Clothilde Laurent, Roger Mieusset, Jean‐Claude Soufir, Jeanne Perrin   +3 more
wiley   +1 more source