Results 21 to 30 of about 48,174 (231)

The Great I-QALY Disaster

INNOVATIONS in Pharmacy, 2020
The QALY is an impossible construct; it defies common sense. It fails completely once we consider the axioms of fundamental measurement. Utilities as ordinal scales cannot be used to create QALYS. The QALY should never have been introduced to support the
Paul Langley
doaj   +1 more source

The social value of a QALY : raising the bar or barring the raise? [PDF]

, 2011
Background: Since the inception of the National Institute for Health and Clinical Excellence (NICE) in England, there have been questions about the empirical basis for the cost-per-QALY threshold used by NICE and whether QALYs gained by different ...
Wildman John, Lancsar, Emily, Cam Donaldson, Loomes, G., Prades, J. L. P., Mason, Helen, Wildman, J., Lancsar, E., Robert Sugden, Loomes, Graham, Mandy Ryan, Smith, Richard, Angela Robinson, Wildman, John, Jones-Lee, M. W., Baker Rachel, Baker, Rachel, Ryan Mandy, Shackley Phil, Robinson, Angela, Bateman Ian, Smith Richard, Bateman, Ian, Robinson, A., Ryan, Mandy, Jones-Lee, Michael, Mason Helen, Michael Jones-Lee, Emily Lancsar, Shackley, Phil, Donaldson, C., Sugden, R., Bateman, I.., Richard Smith, John Wildman, Loomes Graham, Prades Jose, Baker, R., Pinto Prades, Jose Luis, Smith, R., Jones-Lee Michael, Ryan, M., Mason, H., Jose Luis Pinto Prades, Phil Shackley, Shackley, P., Robinson Angela, Helen Mason, Sugden Robert, Jones-Lee, M., Donaldson, Cam, Ian Bateman, Rachel Baker, Sugden, Robert, Sugden, R. C., Graham Loomes, Lancsar Emily, Prades, Jose Luis Pinto, Baker, Rachel M.; id_orcid, Donaldson Cam   +59 more
core   +2 more sources

Searchers vs surveyors in estimating the monetary value of a QALY: resolving a nasty dilemma for NICE. [PDF]

, 2011
Recently, for many health economics researchers, empirical estimation of the monetary valuation of a quality-adjusted life year (QALY) has become an important endeavour. Different philosophical and practical approaches to this have emerged.
Lancsar, Emily, Wildman, John, Helen Mason, Cam Donaldson, Baker, Rachel, Donaldson, Cam, Hugh Metcalf, John Wildman, Rachel Baker, Mason, Helen, Chilton, Sue, Chilton, Susan, Jones-Lee, Michael, Pennington, Mark, Metcalf, Hugh, Mark Pennington, Michael Jones-Lee, Baker, Rachel M.; id_orcid, Sue Chilton, Emily Lancsar   +19 more
core   +1 more source

THE USE OF PALBOCKLIB, A CYCLINE-DEPENDENT KINASE 4/6 INHIBITOR, IN THE TREATMENT OF METASTATIC BREAST CANCER. A COST-CONSEQUENCE ANALYSIS

Сибирский онкологический журнал, 2017
A new generation of aromatase inhibitors and target therapy directed at cycline-dependent kinases 4 and 6 gives a new opportunity to treat metastatic breast cancer. However, the cost of innovative therapy remains high.
S. L. Pavlinsky, P. I. Shabalkin
doaj   +1 more source

VALIDATION OF THE RUSSIAN VERSION OF A QUESTIONNAIRE FOR THE ASSESSMENT OF UTILITARIAN INDICES IN PEDIATRIC PRACTICE. STAGE II

Вопросы современной педиатрии, 2014
Aim: To create the Russian-language version of the standardized international questionnaire Health Utilities Index (HUI) applicable for children's age, on the basis of the relevant international requirements to linguistic ratification and validation of ...
I. V. Vinyarskaya, V. V. Chernikov, R. N. Terletskaya, S. V. Shcherbakova, А. N. Fetisova   +4 more
doaj   +1 more source

Health economic evaluation of gene replacement therapies: methodological issues and recommendations

Journal of Market Access & Health Policy, 2020
Objective: To provide recommendations for addressing previously identified key challenges in health economic evaluations of Gene Replacement Therapies (GRTs), including: 1) the assessment of clinical effectiveness; 2) the valuation of health outcomes; 3)
Samuel Aballéa, Katia Thokagevistk, Rimma Velikanova, Steven Simoens, Lieven Annemans, Fernando Antonanzas, Pascal Auquier, Clément François, Frank-Ulrich Fricke, Daniel Malone, Aurélie Millier, Ulf Persson, Stavros Petrou, Omar Dabbous, Maarten Postma, Mondher Toumi   +15 more
doaj   +1 more source

DEVELOPMENT AND VALIDATION OF THE RUSSIAN VERSION OF THE QUESTIONNAIRE FOR THE UTILITARIAN INDEXES EVALUATION IN PEDIATRICIAN PRACTICE

Педиатрическая фармакология, 2012
Health-related quality of life (HRQL) is a value correlating with life duration, which depends on person’s disturbances, current functional condition, self-perception and social abilities, which are influenced by diseases, traumas, treatment and private ...
A. A. Baranov, V. J. Albitskiy, I. V. Vinyarskaya, V. V. Tchernikov, N. V. Ustinova, O. I. Simonova, J. V. Gorinova, M. S. Samsonova   +7 more
doaj   +1 more source

QALYs: The Basics

Value in Health, 2009
The aim of this article is to review the concept of the qualityadjusted life-year (QALY), a widely used measure of health improvement that is used to guide health-care resource allocation decisions. The QALY was originally developed as a measure of health effectiveness for cost-effectiveness analysis, a method intended to aid decision-makers charged ...
Weinstein, Milton C., Torrance, George, McGuire, Alistair   +2 more
openaire   +2 more sources

Measurement, modeling and QALYs [PDF]

F1000Research, 2020
Over the past 30 years, a mainstay of health technology assessment has been the creation of modeled incremental cost-per-quality adjusted life year (QALY) claims. These are intended to inform resource allocation decisions. Unfortunately, the reliance on the construction of QALYs from generic utility scales is misplaced.
Paul C. Langley, Stephen P. McKenna
openaire   +2 more sources

Modelling Spillover Effects on Informal Carers: The Carer QALY Trap [PDF]

, 2023
The provision of informal (unpaid) care can impose significant 'spillover effects' on carers, and accounting for these effects is consistent with the efficiency and equity objectives of health technology assessment (HTA).
Schirrmacher, H., Chris Skedgel, Shah, K.K., David J. Mott, Hannah Schirrmacher, Al-Janabi, Hareth; id_orcid, Guest, S., Al-Janabi, H., Guest, Sophie, Koonal K. Shah, Hareth Al-Janabi, Schirrmacher, Hannah, Mott, D.J., Sophie Guest, Shah, Koonal K, Pennington, Becky, Mott, David J, Becky Pennington, Scheuer, N., Nicolas Scheuer, Skedgel, C., Scheuer, Nicolas, Skedgel, Chris, Pennington, B.   +23 more
core   +1 more source