Results 1 to 10 of about 146,811 (101)
Dosage regulation of the active X chromosome in human triploid cells. [PDF]
PLoS Genetics, 2009 In mammals, dosage compensation is achieved by doubling expression of X-linked genes in both sexes, together with X inactivation in females. Up-regulation of the active X chromosome may be controlled by DNA sequence-based and/or epigenetic mechanisms ...
Xinxian Deng +5 more
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Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression. [PDF]
PLoS Genetics, 2009 The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain.
Marc Lavigne +9 more
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Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor. [PDF]
PLoS Genetics, 2011 Understanding the genetic, structural, and biophysical mechanisms that caused protein functions to evolve is a central goal of molecular evolutionary studies.
Sean Michael Carroll +2 more
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The Alternative Sigma Factor SigX Controls Bacteriocin Synthesis and Competence, the Two Quorum Sensing Regulated Traits in Streptococcus mutans. [PDF]
PLoS Genetics, 2015 Two small quorum sensing (QS) peptides regulate competence in S. mutans in a cell density dependent manner: XIP (sigX inducing peptide) and CSP (competence stimulating peptide). Depending on the environmental conditions isogenic S. mutans cells can split
Michael Reck +2 more
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A Tracing Model for the Evolutionary Equilibrium of Octoploids
Frontiers in Genetics, 2022 Testing Hardy-Weinberg equilibrium (HWE) is a fundamental approach for inferring population diversity and evolution, but its application to octoploids containing eight chromosome sets has not well been justified.
Jing Wang +5 more
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Pathways of distinction analysis: a new technique for multi-SNP analysis of GWAS data. [PDF]
PLoS Genetics, 2011 Genome-wide association studies (GWAS) have become increasingly common due to advances in technology and have permitted the identification of differences in single nucleotide polymorphism (SNP) alleles that are associated with diseases.
Rosemary Braun, Kenneth Buetow
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Frontiers in Genetics, 2022 Alternative polyadenylation (APA) is widespread among metazoans and has been shown to have important impacts on mRNA stability and protein expression. Beyond a handful of well-studied organisms, however, its existence and consequences have not been well ...
Leonard Schärfen +10 more
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Characterization of Chromosomal Instability in Glioblastoma
Frontiers in Genetics, 2022 Glioblastoma multiforme (GBM) is a malignant tumor of the central nervous system (CNS). The poor prognosis of GBM due to resistance to therapy has been associated with high chromosomal instability (CIN).
Elisa Balzano +6 more
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Frontiers in Genetics, 2022 Residual feed intake (RFI) is considered as a measurement of feed efficiency, which is greatly related to the growth performance in pigs. Daily feeding records can be obtained from automatic feeders.
Ye Wang +11 more
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Frontiers in Genetics, 2022 Gastric cancer (GC), which has high morbidity and low survival rate, is one of the most common malignant tumors in the world. The increasing evidences show that the tumor microenvironment (TME) is related to the occurrence and progression of tumors and ...
Qian Wang +9 more
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