Results 11 to 20 of about 146,455 (101)

A Randomized, Controlled Comparison of NCX 470 (0.021%, 0.042%, and 0.065%) and Latanoprost 0.005% in Patients With Open-angle Glaucoma or Ocular Hypertension: The Dolomites Study

Journal of glaucoma, 2022
Précis: NCX 470 0.042% and 0.065% were statistically superior in intraocular pressure (IOP) lowering to latanoprost 0.005%, and NCX 470 0.021% was noninferior. All NCX 470 concentrations were safe and well tolerated.
T. Walters, Angela C Kothe, J. Boyer, D. Usner, Krisol Lopez, B. Duquesroix, R. Fechtner, Tomas Navratil   +7 more
semanticscholar   +1 more source

Berberine Suppresses Mice Depression Behaviors and Promotes Hippocampal Neurons Growth Through Regulating the miR-34b-5p/miR-470-5p/BDNF Axis

Neuropsychiatric Disease and Treatment, 2021
Background Berberine has been found to inhibit the progression of depression disorder, but its specific mechanism is still unclear. MicroRNA (miRNA) is considered to play an important role in the progression of depression.
Yuhua Zhan, Jiyang Han, Jing Xia, Xumei Wang   +3 more
semanticscholar   +1 more source

Demography and selection analysis of the incipient adaptive radiation of a Hawaiian woody species.

PLoS Genetics, 2022
Ecological divergence in a species provides a valuable opportunity to study the early stages of speciation. We focused on Metrosideros polymorpha, a unique example of the incipient radiation of woody species, to examine how an ecological divergence ...
Ayako Izuno, Yusuke Onoda, Gaku Amada, Keito Kobayashi, Mana Mukai, Yuji Isagi, Kentaro K Shimizu   +6 more
doaj   +1 more source

Mitochondrial Displacement Loop Region SNPs Modify Sjögren’s Syndrome Development by Regulating Cytokines Expression in Female Patients

Frontiers in Genetics, 2022
Mitochondrial dysfunction could induce innate immune response with cytokines releasing to initiate Sjögren’s syndrome (SS) onset. Single nucleotide polymorphisms (SNPs) in the mitochondrial displacement loop (D-loop) and mitochondrial DNA (mtDNA) copy ...
Yufei Zhao, Chenxing Peng, Jingjing Zhang, Ruixue Lai, Xiaoyun Zhang, Zhanjun Guo   +5 more
doaj   +1 more source

Patient characteristics and predictors of mortality in 470 adults admitted to a district general hospital in England with Covid-19

Epidemiology and Infection, 2020
Understanding risk factors for death from Covid-19 is key to providing good quality clinical care. We assessed the presenting characteristics of the ‘first wave’ of patients with Covid-19 at Royal Oldham Hospital, UK and undertook logistic regression ...
J. Thompson, N. Meghani, B. Powell, I. Newell, R. Craven, G. Skilton, L. J. Bagg, I. Yaqoob, M. Dixon, E. Evans, B. Kambele, Aziz Ur Rehman, G. Ng Man Kwong   +12 more
semanticscholar   +1 more source

Systematic mapping of rRNA 2'-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis.

PLoS Genetics, 2022
Ribosomes are essential nanomachines responsible for protein production. Although ribosomes are present in every living cell, ribosome biogenesis dysfunction diseases, called ribosomopathies, impact particular tissues specifically.
Jonathan Delhermite, Lionel Tafforeau, Sunny Sharma, Virginie Marchand, Ludivine Wacheul, Ruben Lattuca, Simon Desiderio, Yuri Motorin, Eric Bellefroid, Denis L J Lafontaine   +9 more
doaj   +1 more source

Germline Mutation Analysis in Sporadic Breast Cancer Cases With Clinical Correlations

Frontiers in Genetics, 2022
Demographics for breast cancers vary widely among nations. The frequency of germline mutations in breast cancers, which reflects the hereditary cases, has not been investigated adequately and accurately in highly-consanguineous Pakistani population.
Sadia Ajaz, Sadia Ajaz, Sani-e-Zehra Zaidi, Saleema Ali, Aisha Siddiqa, Muhammad Ali Memon   +5 more
doaj   +1 more source

Molecular Mechanism of the UDP-Glucuronosyltransferase 2B20-like Gene (AccUGT2B20-like) in Pesticide Resistance of Apis cerana cerana

Frontiers in Genetics, 2020
UDP-glucuronosyltransferases (UGTs), being multifunctional detoxification enzymes, play a major role in the process of resistance to various pesticides in insects. However, the mechanism underlying the molecular regulation of pesticide resistance remains
Xuepei Cui, Chen Wang, Xinxin Wang, Guilin Li, Zhenguo Liu, Hongfang Wang, Xingqi Guo, Baohua Xu   +7 more
doaj   +1 more source

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.

PLoS Genetics, 2022
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset disorder characterized by progressive weakness and degeneration of specific muscles. OPMD is due to extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1).
Cécile Ribot, Cédric Soler, Aymeric Chartier, Sandy Al Hayek, Rima Naït-Saïdi, Nicolas Barbezier, Olivier Coux, Martine Simonelig   +7 more
doaj   +1 more source

Multi-Omics Analysis to Examine Gene Expression and Metabolites From Multisite Adipose-Derived Mesenchymal Stem Cells

Frontiers in Genetics, 2021
This study aimed at exploring the gene expression and metabolites among multisite adipose-derived mesenchymal stem cells (ASCs) and investigate the metabolic pathway using a multi-omics analysis. Subcutaneous adipose-derived mesenchymal stem cells (SASCs)
Chuanxi Yang, Jing Zhang, Tingting Wu, Kun Zhao, Xiaoguang Wu, Jing Shi, Wei Sun, Xiangqing Kong   +7 more
doaj   +1 more source