Results 31 to 40 of about 146,455 (101)

Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns

open access: yesEpigenetics & Chromatin, 2022
Background The epigenetic age can now be extrapolated from one of several epigenetic clocks, which are based on age-related changes in DNA methylation levels at specific multiple CpG sites.
Tamar Shahal   +9 more
doaj   +1 more source

Phase II Study of Adjuvant Immunotherapy with the CSF-470 Vaccine Plus Bacillus Calmette–Guerin Plus Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor vs Medium-Dose Interferon Alpha 2B in Stages IIB, IIC, and III Cutaneous Melanoma Patients: A Single Institution, Randomized Study

open access: yesFrontiers in Immunology, 2017
The irradiated, allogeneic, cellular CSF-470 vaccine plus Bacillus Calmette–Guerin (BCG) and recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) is being tested against medium-dose IFN-α2b in stages IIB–III cutaneous melanoma ...
J. Mordoh   +13 more
semanticscholar   +1 more source

LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites

open access: yesMobile DNA, 2020
Background Ligation-mediated PCR protocols have diverse uses including the identification of integration sites of insertional mutagens, integrating vectors and naturally occurring mobile genetic elements.
Joanna C. Dawes   +14 more
doaj   +1 more source

Case Report: Infantile Cerebellar-Retinal Degeneration With Compound Heterozygous Variants in ACO2 Gene—Long-Term Follow-Up of a Sibling

open access: yesFrontiers in Genetics, 2022
Infantile cerebellar-retinal degeneration (ICRD) is an extremely rare, infantile-onset neuro-degenerative disease, characterized by autosomal recessive inherited, global developmental delay (GDD), progressive cerebellar and cortical atrophy, and retinal ...
Dong Jun Ha   +10 more
doaj   +1 more source

Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update

open access: yesFrontiers in Genetics, 2020
There is a growing interest in standardizing gene-disease associations for the purpose of facilitating the proper classification of variants in the context of Mendelian diseases.
Sateesh Maddirevula   +34 more
doaj   +1 more source

Single Cell Transcriptome Sequencing of Zebrafish Testis Revealed Novel Spermatogenesis Marker Genes and Stronger Leydig-Germ Cell Paracrine Interactions

open access: yesFrontiers in Genetics, 2022
Spermatogenesis in testis is an important process for sexual reproduction, and worldwide about 10–15 percent of couples suffer from infertility. It is of importance to study spermatogenesis at single cell level in both of human and model organisms ...
Peipei Qian   +3 more
doaj   +1 more source

Effects of AVX-470, an Oral, Locally Acting Anti-Tumour Necrosis Factor Antibody, on Tissue Biomarkers in Patients with Active Ulcerative Colitis.

open access: yesJournal of Crohn's & Colitis, 2016
BACKGROUND AND AIMS AVX-470 is an orally administered, bovine-derived, anti-tumour necrosis factor (TNF) antibody with local activity in the gastrointestinal tract.
D. Hartman   +10 more
semanticscholar   +1 more source

Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

open access: yesFrontiers in Genetics, 2022
Background: Androgen alopecia (AGA), the most common type of alopecia worldwide, has become an important medical and social issue. Accumulating evidence indicates that long noncoding RNAs (lncRNAs) play crucial roles in the progression of various human ...
Jiachao Xiong   +6 more
doaj   +1 more source

Intraocular Pressure-Lowering Activity of NCX 470, a Novel Nitric Oxide-Donating Bimatoprost in Preclinical Models.

open access: yesInvestigative Ophthalmology and Visual Science, 2015
PURPOSE The prostaglandin F2alpha (PGF2α) analogue bimatoprost lowers intraocular pressure (IOP) by increasing uveoscleral outflow at doses shown to elicit redness of the eye.
F. Impagnatiello   +7 more
semanticscholar   +1 more source

Genomic Reporter Constructs to Monitor Pathway-Specific Repair of DNA Double-Strand Breaks

open access: yesFrontiers in Genetics, 2022
Repair of DNA Double-Strand Breaks (DSBs) can be error-free or highly mutagenic, depending on which of multiple mechanistically distinct pathways repairs the break.
Bert van de Kooij, Haico van Attikum
doaj   +1 more source

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