Results 41 to 50 of about 152,996 (99)
Feeding state, insulin and NPR-1 modulate chemoreceptor gene expression via integration of sensory and circuit inputs. [PDF]
PLoS Genetics, 2014 Feeding state and food availability can dramatically alter an animals' sensory response to chemicals in its environment. Dynamic changes in the expression of chemoreceptor genes may underlie some of these food and state-dependent changes in chemosensory ...
Matthew Gruner +8 more
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Blood Advances, 2018 Fumagillin is an antiangiogenic and antineoplastic fungal natural product, and TNP-470 is one of its most potent analogs. Decades of studies revealed that TNP-470 has potent anticancer activities via destruction of neovasculature.
D. Ho, R. Wong
semanticscholar +1 more source
Frontiers in Genetics, 2017 Several factors have been proposed as contributors to interfamilial and intrafamilial phenotypic variability in autosomal dominant disorders, including allelic variation, modifier genes, environmental factors and complex genetic and environmental ...
Baoheng Gui +3 more
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Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke. [PDF]
PLoS Genetics, 2013 During ischemic stroke, occlusion of the cerebrovasculature causes neuronal cell death (infarction), but naturally occurring genetic factors modulating infarction have been difficult to identify in human populations.
Sehoon Keum +8 more
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The struggle to find reliable results in exome sequencing data: Filtering out Mendelian errors
Frontiers in Genetics, 2014 Next Generation Sequencing studies generate a large quantity of genetic data in a relatively cost and time efficient manner and provide an unprecedented opportunity to identify candidate causative variants that lead to disease phenotypes.
Zubin Hasmukh Patel +20 more
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Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs. [PDF]
PLoS Genetics, 2013 The Elongator complex, including the histone acetyl transferase Sin3/Elp3, was isolated as an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display transcriptional defects. However, it has also been shown that Elongator
Jorge Fernández-Vázquez +10 more
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A model-based analysis of GC-biased gene conversion in the human and chimpanzee genomes. [PDF]
PLoS Genetics, 2013 GC-biased gene conversion (gBGC) is a recombination-associated process that favors the fixation of G/C alleles over A/T alleles. In mammals, gBGC is hypothesized to contribute to variation in GC content, rapidly evolving sequences, and the fixation of ...
John A Capra +4 more
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ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. [PDF]
PLoS Genetics, 2013 Zinc is an essential metal involved in a wide range of biological processes, and aberrant zinc metabolism is implicated in human diseases. The gastrointestinal tract of animals is a critical site of zinc metabolism that is responsible for dietary zinc ...
Hyun Cheol Roh +5 more
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Journal of Veterinary Internal Medicine, 2014 Background Many chemotherapy protocols have been reported for treatment of canine appendicular osteosarcoma (OSA), but outcome comparisons in a single population are lacking.
L. Selmic +4 more
semanticscholar +1 more source
Frontiers in Genetics, 2018 The commensal yeast Candida albicans is an opportunistic pathogen. In order to successfully colonize or infect the human body, the fungus must adapt to the host’s environmental conditions, such as low oxygen tension (hypoxia), temperature (37°C), and the
Thais F. Bartelli +4 more
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