Results 11 to 20 of about 6,266 (205)
A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli [PDF]
eLife, 2021 The plasmid-mediated quinolone resistance (PMQR) genes have been shown to promote high-level bacterial resistance to fluoroquinolone antibiotics, potentially leading to clinical treatment failures.
Anamaria Babosan +13 more
semanticscholar +7 more sources
Chromosomal Mutations that Accompany qnr in Clinical Isolates of Escherichia coli
International Journal of Antimicrobial Agents, 2018 We examined 13 qnr-positive and 14 qnr-negative clinical isolates of Escherichia coli for mutations previously seen in a qnr-containing laboratory strain exposed to supra MIC concentrations of ciprofloxacin.
L. Vinué, D. Hooper, G. Jacoby
semanticscholar +4 more sources
Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli [PDF]
Journal of Antimicrobial Chemotherapy, 2017 Background Ciprofloxacin, a fluoroquinolone, targets two essential bacterial enzymes, DNA gyrase and topoisomerase IV. Plasmid-borne qnr genes, encoding proteins that protect DNA gyrase and topoisomerase IV from inhibition by fluoroquinolones, contribute
L. Garoff, K. Yadav, D. Hughes
semanticscholar +4 more sources
[qnr genes in Enterobacteriaceae isolated from at a hospital in Venezuela].
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2018 BACKGROUND Enterobacteria resistant to quinolones is increasing worldwide, including Venezuela. The mechanism for this resistance could be due to genes included in the chromosome or in transmissible plasmids.
J. García +7 more
semanticscholar +3 more sources
Analysis of the presence of erroneous Qnr sequences in GenBank [PDF]
Journal of Antimicrobial Chemotherapy, 2018 Twenty years ago the first transferable mechanism of quinolone resistance (TMQR), QnrA, was described. Thereafter, innumerable TMQRs, either Qnr related or not, were described. Ten years ago the exponential description of Qnr genes/alleles led to the proposal of a common nomenclature.This analysis aims to determine the degree of correctness of the Qnr ...
J. Ruiz
semanticscholar +3 more sources
Effect of Qnr on Plasmid Gyrase Toxins CcdB and ParE [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT Plasmid toxins CcdB and ParE are part of addiction systems promoting plasmid maintenance. Both target host DNA gyrase, as do quinolones and plasmid-determined Qnr proteins that protect gyrase from quinolone inhibition. We cloned qnrB4 , qnrS1 , ccdB ,
Y. Kwak, G. Jacoby, D. Hooper
semanticscholar +3 more sources
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Determinants showing plasmid-mediated quinolone resistance, which usually leads to antimicrobial ineffectiveness, have become an emerging clinical problem. In our previous study in the Philippines, a high prevalence of qnr determinants was
Lawrence P. Belotindos +5 more
doaj +1 more source
BMC Microbiology, 2022 Conjugative plasmids play a major role in the dissemination of antibiotic resistance genes. Knowledge of the plasmid characteristics and behaviour can allow development of control strategies.
Tomas Nohejl +7 more
semanticscholar +1 more source
Plasmid-Mediated Mechanism of Quinolone Resistance on E. coli Isolates from Different Clinical Samples [PDF]
Archives of Razi Institute, 2021 Quinolone antimicrobials are widely used in clinical medicine due to their wide spectrum with high tissue penetration and ease of use; but increasing resistance with clinical use appears to be common in some bacterial pathogens, including Escherichia ...
I Fadhil Abdul-Husin +1 more
doaj +1 more source
Antimicrobial Agents and Chemotherapy, 2008 Since the plasmid-borne quinolone resistance gene qnr was reported in 1998 (8), many additional qnr alleles have been discovered on plasmids or the bacterial chromosome (reviewed in references 9 and 13). The plasmid-borne qnr genes currently comprise three families, qnrA, qnrB, and qnrS, differing from each other 40% or more in nucleotide sequence ...
George, Jacoby +7 more
openaire +2 more sources