Results 11 to 20 of about 4,982 (162)
Decreased plasma Aβ in hyperlipidemic APPSL transgenic mice is associated with BBB dysfunction
Frontiers in Neuroscience, 2016 Besides the continued focus on Aβ and Tau in Alzheimer’s disease (AD), it is increasingly evident that other pathologic characteristics, such as vascular alterations or inflammation, are associated with AD.
Tina eLöffler +3 more
doaj +1 more source
CURRENT ALGEBRAS AND QP-MANIFOLDS [PDF]
International Journal of Geometric Methods in Modern Physics, 2013 Generalized current algebras introduced by Alekseev and Strobl in two dimensions are reconstructed by a graded manifold and a graded Poisson brackets. We generalize their current algebras to higher dimensions. QP-manifolds provide the unified structures of current algebras in any dimension.
Ikeda, Noriaki, Koizumi, Kozo
openaire +2 more sources
EFSA Journal, 2020 The qualified presumption of safety (QPS) was developed to provide a safety pre‐assessment within EFSA for microorganisms. Strains belonging to QPS taxonomic units (TUs) still require an assessment based on a specific data package, but QPS status ...
EFSA Panel on Biological Hazards (BIOHAZ) +26 more
doaj +1 more source
Phosphorylation of different tau sites during progression of Alzheimer’s disease
Acta Neuropathologica Communications, 2018 Alzheimer’s disease is characterized by accumulation of amyloid plaques and tau aggregates in several cortical brain regions. Tau phosphorylation causes formation of neurofibrillary tangles and neuropil threads.
Joerg Neddens +9 more
doaj +1 more source
Hepatic and neuronal phenotype of NPC1−/− mice
Heliyon, 2019 Niemann-Pick type C disease (NPC) is a fatal autosomal recessive disorder characterized by a defect in the intracellular transport of lipoproteins leading to the accumulation of lipids in diverse tissues. A visceral and neuronal phenotype mimicking human
Estibaliz Santiago-Mujica +5 more
doaj +1 more source
EFSA Journal, 2023 The qualified presumption of safety (QPS) provides a generic pre‐assessment of the safety of microorganisms intended for use in the food or feed chains, to support the work of EFSA's Scientific Panels.
EFSA Panel on Biological Hazards (BIOHAZ) +27 more
doaj +1 more source
Improved bioavailability of cromolyn sodium using inhaled PA101 delivered via eFlow® nebulizer
European Clinical Respiratory Journal, 2020 In 1960s, cromolyn sodium (CS) has been introduced as the first non-steroidal anti-inflammatory drug for the treatment of allergic and mast-cell driven diseases. Its applicability has been limited due to a poor bioavailability.
Khalid Abd-Elaziz +2 more
doaj +1 more source
Clinical Neurophysiology Practice, 2023 Objective: This study aimed to assess the efficacy and safety of quadripulse transcranial magnetic stimulation-50 (QPS-50) in patients with intractable epilepsy. Methods: Four patients were included in the study.
Setsu Nakatani-Enomoto +13 more
doaj +1 more source
EFSA Journal, 2020 Qualified presumption of safety (QPS) was developed to provide a generic safety evaluation for biological agents to support EFSA's Scientific Panels. The taxonomic identity, body of knowledge, safety concerns and antimicrobial resistance are assessed ...
EFSA Panel on Biological Hazards (BIOHAZ) +26 more
doaj +1 more source
Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase
Medicine in Drug Discovery, 2020 Aims: Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol ...
Abdul Burhan Khan +7 more
doaj +1 more source