Results 131 to 140 of about 1,108,829 (262)

qRT-PCR validated miRNAs and their targets in the PH6WC and PH4CV lines.

, 2016
qRT-PCR validated miRNAs and their targets in the PH6WC and PH4CV lines.
Yu-Min Guo (3146568), Cheng-Yi Tang (3146571), Gui-Hua Lu (3110931), Min-Kai Yang (3146562), Feng-Yao Wu (3146565), Yong-Hua Yang (13701), Rong-Wu Yang (3146559)   +6 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

qRT-PCR analysis of genes related to antioxidant enzymes in ‘Shatangju’ mandarin.

, 2017
Data indicating relative transcript level from qRT-PCR are means of three biological replicates.
Jie-Zhong Chen (3637504), Qing Yao (56578), Xiang-Yu Liu (258990), Meng-Meng Liu (640371), Juan Li (146180)   +4 more
core   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

qRT-PCR validation of selected unigenes in the MEP, MVA, and terpene biosynthetic pathways.

, 2018
qRT-PCR validation of selected unigenes in the MEP, MVA, and terpene biosynthetic pathways.
Xiuxian Ye (5720666), Huaiqin Zhong (5720669), Yiquan Chen (5720663), Ronghui Fan (5720660), Jianshe Wu (453816), Bing Lin (136655)   +5 more
core   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

Advanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai   +8 more
wiley   +1 more source

qRT-PCR analysis of genes related to growth regulating factors in ‘Shatangju’ mandarin.

, 2017
Data indicating relative transcript level from qRT-PCR are means of three biological replicates.
Jie-Zhong Chen (3637504), Qing Yao (56578), Xiang-Yu Liu (258990), Meng-Meng Liu (640371), Juan Li (146180)   +4 more
core   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Qrt-PCR validation of 12randomly selected differentially expressed genes (DEGs) detected by RNA-seq.

, 2018
Qrt-PCR validation of 12randomly selected differentially expressed genes (DEGs) detected by RNA-seq.
ShengChao Zhao (5513588), Yonggang Gao (459194), LiJuan Zhang (5513585), Yuanxin Yan (276632)   +3 more
core   +1 more source