Characterising QT interval prolongation in early clinical development: a case study with methadone [PDF]
, 2017 Recently, we have shown how pharmacokinetic-pharmacodynamic (PKPD) modelling can be used to assess the probability of QTc interval prolongation both in dogs and humans.
Danhof, M, Della Pasqua, O, Dubois, VFS
core
Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling [PDF]
, 2003 <b>Objective:</b> Chronic beta-adrenoceptor antagonist (β-blocker) treatment reduces the incidence of reversion to AF in patients, possibly via an adaptive myocardial response.
Kane, K.A. +4 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Potential adverse drug events can be signaled in Clinical Decision Support Systems (CDSSs). This study validated a Swedish CDSS (Janusmed Risk Profile) by investigating associations between calculated risk classifications of drugs with QT‐prolonging potential and registered related clinical outcomes.
Ola Nordqvist +6 more
wiley +1 more source
QT Interval Prolongation in Cirrhotic Cardiomyopathy
Research Reports in Clinical Cardiology, 2022 Amanuel Tadelle Department of Biomedical Sciences, Jimma University, Jimma City, EthiopiaCorrespondence: Amanuel Tadelle, Email newaman09@yahoo.com; amanuel.muluneh@ju.edu.etAbstract: The liver and the heart are related to each other in many aspects.
Tadelle A
doaj
Molecular and clinical determinants of drug-induced long QT syndrome: an iatrogenic channelopathy. [PDF]
, 2004 More than 70 drugs present on the Swiss market can cause drug-induced long QT syndrome (LQTS), which is associated with torsades de pointes (TdP) arrhythmias, potentially leading to sudden cardiac death. Basic and clinical investigations performed during
Abriel, H. +7 more
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The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]
, 2012 This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L +5 more
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Itraconazole-induced Torsade de Pointes in a patient receiving methadone substitution therapy [PDF]
, 2009 Issues. Methadone, a pharmacological agent used to treat heroin dependence is relatively safe, but may cause cardiac arrhythmias in the concurrent presence of other risk factors. Approach and Key Findings.
Narayanan, S. +2 more
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Chronic Arsenic Exposure and Cardiac Repolarization Abnormalities with QT Interval Prolongation in a Population-based Study [PDF]
, 2007 BACKGROUND: Chronic arsenic exposure is associated with cardiovascular abnormalities. Prolongation of the QT (time between initial deflection of QRS complex to the end of T wave) interval and profound repolarization changes on electrocardiogram (ECG ...
Ahmad SA +13 more
core +3 more sources
European Journal of Heart Failure, EarlyView.Global patterns of polypharmacy after acute heart failure hospitalization. GDMT, guideline‐directed medical therapy; HF, heart failure. Aims Polypharmacy, defined as the concurrent use of ≥5 medications, is prevalent among older adults with heart failure (HF).
Wan Ting Tay +19 more
wiley +1 more source
Towards understanding the clinical significance of QT peak prolongation: a novel marker of myocardial ischemia independently demonstrated in two prospective studies [PDF]
, 2015 Background: QT peak prolongation identified patients at risk of death or non-fatal MI. We tested the hypothesis that QT peak prolongation might be associated with significant myocardial ischaemia in two separate cohorts to see how widely applicable the ...
Ball, Jeff B +10 more
core +1 more source