Results 91 to 100 of about 55,959 (291)

Population‐Based Study Found Low Risk of Misdiagnosing Long QT Syndrome as Breath‐Holding Spells in Swedish Children

Acta Paediatrica, EarlyView.
ABSTRACT Aim An electrocardiogram is commonly recommended in breath‐holding spell management, mainly to rule out long QT syndrome. This retrospective study investigated the risk of long QT syndrome being misdiagnosed as breath‐holding spells in a paediatric population in southern Sweden.
Sanna Hellström Schmidt, Ida Jeremiasen, Erik A. Eklund, Cornelis Jan Pronk   +3 more
wiley   +1 more source

Drug-Induced QT Prolongation as a Result of an Escitalopram Overdose in a Patient with Previously Undiagnosed Congenital Long QT Syndrome

Case Reports in Medicine, 2014
We present a case of drug-induced QT prolongation caused by an escitalopram overdose in a patient with previously undiagnosed congenital LQTS. A 15-year-old Caucasian female presented following a suicide attempt via an escitalopram overdose.
Paul Singh, J. Martin Maldonado-Duran
doaj   +1 more source

Hepatitis B Virus RNA Predicts Hepatocellular Carcinoma Despite Viral Suppression

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum HBV RNA levels at viral suppression predict HCC development in nucleos(t)ide analogue‐treated patients with chronic hepatitis B, outperforming Hepatitis B core‐related antigen alone. ABSTRACT Background Despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos(t)ide analogue (NA) therapy, patients with chronic hepatitis B ...
Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Yuichi Koshiyama, Takanori Ito, Tomoyuki Akita, Junko Tanaka   +6 more
wiley   +1 more source

The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning

Balkan Medical Journal, 2015
Background: Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning.
Müjgan Büyükdeligöz, Nil Hocaoğlu, Kubilay Oransay, Yeşim Tunçok, Şule Kalkan   +4 more
doaj   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Issues in QT interval measurement

Indian Pacing and Electrophysiology Journal, 2004
The QT interval, apart from clinical implications is crucial for safety assessment of new drugs under development. A QTc prolongation of even 10 msec in a study group is a warning signal for a new drug.
Pallavi Lanjewar, Vaishali Pathak, Yash Lokhandwala   +2 more
doaj  

QT PRODACT: In Vivo QT Assay in Anesthetized Dog for Detecting the Potential for QT Interval Prolongation by Human Pharmaceuticals

Journal of Pharmacological Sciences, 2005
The purpose of this study was to assess the utility of the isoflurane-anesthetized dog model for detecting the potential for QT interval prolongation by human pharmaceuticals.
Hiroyuki Tashibu, Hiroyasu Miyazaki, Kumiko Aoki, Yasuki Akie, Keiji Yamamoto   +4 more
doaj   +1 more source

Systematic Review and Meta‐Analysis of Mortality in Patients With Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) has one of the highest mortality rates among psychiatric disorders. This systematic review and meta‐analysis examined the all‐cause mortality of AN patients compared to the general population using the standardized mortality ratio (SMR).
Eric Tsz‐Him Lai, Benjamin Lai, Corine Sau‐Man Wong, Lai‐Yi Wong, Kin‐Shing Cheng, Pak‐Wing Calvin Cheng, Lo Heidi Ka‐Ying, Gary Tse, Wai‐Chi Chan, Wing‐Chung Chang, Ka‐Fai Chung   +10 more
wiley   +1 more source

Electrophysiological diagnosis using the coefficient of variation of R‐R intervals and a point‐of‐care nerve conduction device is highly correlated to the diagnosis of diabetic polyneuropathy using conventional electromyographs

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction While treatment for diabetic polyneuropathy (DPN) is still developing, progress has stagnated. The alignment between pathological neurodegeneration in DPN and patients' subjective symptoms is often low, yet these symptoms are frequently used for diagnosis.
Tatsuhito Himeno, Hideki Kamiya, Yuka Shibata, Masato Kase, Hiromi Nakai‐Shimoda, Dai Yamagami, Masahiro Saito, Teruo Jojima, Aiko Arimura, Kenta Murotani, Chieko Suzuki, Hiroki Mizukami, Takahisa Deguchi, Yoshimasa Aso, Jiro Nakamura   +14 more
wiley   +1 more source

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance

Journal of Fish Biology, EarlyView.
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams, Les N. Harris, Jean‐Sébastien Moore, Ella K. Middleton, Shira A. Berkelhammer, Ben Speers‐Roesch, Matthew J. H. Gilbert   +6 more
wiley   +1 more source