Results 131 to 140 of about 73,159 (323)

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Andersen-Tawil Syndrome [PDF]

, 2006
Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Fish, Frank A, Kannankeril, Prince J, Smith, Andrew H   +2 more
core   +2 more sources

Proteomic Biomarkers Are Linked to QTc Interval in Patients With Chronic Heart Failure

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Objective This study investigates the link between circulating proteins and rate‐corrected QT (QTc) interval in patients with heart failure with reduced ejection fraction (HFrEF) and their association with cardiovascular outcomes. Methods and Results We analyzed 197 HFrEF patients from the prospective Serial Biomarker Measurements and New ...
Mylène Barry‐Loncq de Jong, Teun B. Petersen, Sabrina Abou Kamar, Navin Suthahar, Nick van Boven, K. Martijn Akkerhuis, Peter J. van der Spek, Peter D. Katsikis, Rudolf A. de Boer, Victor A. W. M. Umans, Eric Boersma, Folkert W. Asselbergs, Jasper J. Brugts, Sing‐Chien Yap, Isabella Kardys   +14 more
wiley   +1 more source

Model‐Based Meta‐Analysis of the Relationship Between Pioglitazone and Histological Outcomes in Metabolic Dysfunction‐Associated Steatohepatitis Patients

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Given the high prevalence of the population who have metabolic dysfunction‐associated steatohepatitis (MASH), interest is growing in MASH‐targeted treatments. However, currently, there has been only one regulatory approved drug for MASH (Rezdiffra).
Quyen Thi Tran, Tham Thi Bui, Lien Thi Ngo, Bo Ram Yang, In‐Hwan Baek, Van Hung Nguyen, Kyung Ae Lee, Hwi‐yeol Yun, Jung‐woo Chae, Soyoung Lee, Jae Hyun Kim, Woojin Jung   +11 more
wiley   +1 more source

A randomized controlled trial of the short-term effect of rosuvastatin on the corrected QT interval

Scientific Reports
Rosuvastatin can block human ether-a-go-go related gene (hERG) currents and prolong the corrected QT (QTc) interval, but this effect has not been confirmed in the population.
Lijun Zhu, Wenjun Shen, Wanying Hu, Haiwang Guan, Yanwei Wang, Conglin Wang, Jing Lin, Li Chen, Qingjun Jiang   +8 more
doaj   +1 more source

The QT interval in lightning injury with implications for the cessation of metabolism hypothesis [PDF]

An hypothesis is presented to provide an alternative to the Cessation of Metabolism hypothesis often invoked in lightning injury. Cessation of Metabolism has been proposed to explain the observation of good recovery after a prolonged period in cardiac ...
Andrews, Christopher J., Colquhoun, David M., Darveniza, Mat   +2 more
core   +1 more source

Drug-induced QT-interval prolongation and proarrhythmic risk in the treatment of atrial arrhythmias [PDF]

, 2007
Eduard Shantsila, Timothy Watson, Gregory Lip   +2 more
openalex   +1 more source

Bottlebrush Polymer Templates for the Synthesis of Gold Nanostructures and their Applications as Photothermal Agents and SERS Substrates

Small Methods, EarlyView.
A soft‐template approach using bottlebrush polymers (BB) enables the scalable synthesis of gold nanostructures (BB@Au) with strong near infrared II (NIR‐II) photothermal and Surface Enhanced Raman Spectroscopy activity. BB@Au nanoparticles exhibit efficient tumor ablation in 2D and 3D models, high biocompatibility in zebrafish assays, and excellent ...
Deepak S. Chauhan, Hu Zhang, Jordan Robert, Malama Chisanga, Jean Michel Rabanel, Dikran Mekhjian, Charlotte Zaouter, Quoc Thang Phan, Wojciech Raj, Sergiy Patskovsky, Shunmoogum A. Patten, Éric Samarut, Jean‐François Masson, Xavier Banquy   +13 more
wiley   +1 more source

Intervalo QT em doentes com hipertensão arterial: estudo por electrocardiograma [PDF]

, 2011
A hipertensão arterial (HTA) é um grave problema de saúde pública que afecta milhares de pessoas em todo o mundo. Apresenta uma elevada prevalência nas sociedades modernas, sendo um importantíssimo factor de risco para as doenças cardiovasculares.
Coelho, Patrícia, Pereira, Alexandre, Pereira, Telmo, Robalo, Diogo   +3 more
core  

Additive Manufacturing of Hot‐Work Tool Steel by In Situ Alloying Using Laser Powder Bed Fusion and Directed Energy Deposition—Strategies to Improve Chemical Homogeneity

steel research international, EarlyView.
To support future alloy development a powder mixture is processed by laser additive manufacturing. The powder mixture containing Mo‐ and W‐rich tracers is processed by powder bed fusion using single and double laser exposure and by directed energy deposition which provides drastically enlarged melt pools.
Felix Großwendt, Sebastian Weber, Jonathan Lentz   +2 more
wiley   +1 more source