Results 71 to 80 of about 40,628 (317)

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

Of buds and bits: a meta-QTL study identifies stable QTL for berry quality and yield traits in cranberry mapping populations (Vaccinium macrocarpon Ait.)

Frontiers in Plant Science
IntroductionFor nearly two centuries, cranberry (Vaccinium macrocarpon Ait.) breeders have improved fruit quality and yield by selecting traits on fruiting stems, termed “reproductive uprights.” Crop improvement is accelerating rapidly in contemporary ...
Andrew F. Maule, Andrew F. Maule, Jenyne Loarca, Jenyne Loarca, Luis Diaz-Garcia, Hector Lopez-Moreno, Hector Lopez-Moreno, Jennifer Johnson-Cicalese, Jennifer Johnson-Cicalese, Nicholi Vorsa, Nicholi Vorsa, Massimo Iorizzo, Massimo Iorizzo, Jeffrey L. Neyhart, Juan E. Zalapa   +14 more
doaj   +1 more source

A critical evaluation of the effect of population size and phenotypic measurement on QTL detection and localization using a large F2 murine mapping population

Genetics and Molecular Biology, 2006
Population size and phenotypic measurement are two key factors determining the detection power of quantitative trait loci (QTL) mapping. We evaluated how these two controllable factors quantitatively affect the detection of QTL and their localization ...
Xinmin Li, Richard J Quigg, Jian Zhou, Shizhong Xu, Godfred Masinde, Subburaman Mohan, David J. Baylink   +6 more
doaj   +1 more source

Unravelling Twin Births in German Holstein Cows: Phenotypic Associations, Genetic Analysis and Potential Underlying Genes and Hormones

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Twin births in dairy cattle are rare but present significant challenges for animal welfare, as both the health of the cow and the calves are affected. This causes economic losses, which prompts breeders to select against twin births and identify associated risk factors.
Laura Hüneke, Hatem Alkhoder, Dierck Segelke, Georg Thaller, Christin Schmidtmann   +4 more
wiley   +1 more source

PEMETAAN QUANTITATIVE TRAIT LOCI UNTUK SIFAT BERSKALA KATEGORIK

Jurnal Ilmu Pertanian Indonesia, 2007
Genes or regions on chromosome underlying a quantitative trait are called quantitative trait loci (QTL). Characterizing genes controlling quantitative trait on their position in chromosome and their effect on trait is through a process called QTL mapping.
Farit Mochamad Afendi
doaj  

A simulation study on the accuracy of position and effect estimates of linked QTL and their asymptotic standard deviations using multiple interval mapping in an F₂ scheme

Genetics Selection Evolution, 2004
Approaches like multiple interval mapping using a multiple-QTL model for simultaneously mapping QTL can aid the identification of multiple QTL, improve the precision of estimating QTL positions and effects, and are able to identify patterns and ...
Freyer Gertraude, Liu Yuefu, Mayer Manfred   +2 more
doaj   +1 more source

Genomic Prediction Ability for Novel Profitability Traits Using Different Models in Nelore Cattle

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The aim of this study was to assess the accuracy, bias and dispersion of genomic predictions for accumulated profitability (APF) and profit per kilogram of liveweight gain (PFT) in Nelore cattle using different prediction approaches. The dataset consisted of 3969 phenotypic records for each trait. The pedigree harboured information from 38,930
Letícia Silva Pereira, Cláudio Ulhôa Magnabosco, Guilherme Rosa, Nedenia Bonvino Stafuzza, Tiago Zanett Albertini, Minos Carvalho, Raysildo Barbosa Lobo, Elisa Peripolli, Eduardo da Costa Eifert, Fernando Baldi   +9 more
wiley   +1 more source

MVQTLCIM: composite interval mapping of multivariate traits in a hybrid F1 population of outbred species

BMC Bioinformatics, 2017
Background With the plummeting cost of the next-generation sequencing technologies, high-density genetic linkage maps could be constructed in a forest hybrid F1 population. However, based on such genetic maps, quantitative trait loci (QTL) mapping cannot
Fenxiang Liu, Chunfa Tong, Shentong Tao, Jiyan Wu, Yuhua Chen, Dan Yao, Huogen Li, Jisen Shi   +7 more
doaj   +1 more source

Genomic Analysis of Taurine and Indicine Ancestry in the Montana Tropical Composite Population

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The Montana Tropical cattle, a Taurine and Indicine composite, were developed in Brazil since 1994 and were based on crossing four biological types of cattle: zebu (mainly Nelore), tropical adapted taurine (mainly Senepol and Romosinuano), British taurine (mainly Angus) and continental taurine (as Charolais, Simental and Limousin).
Camila Alves dos Santos, El Hamidi Hay, Elisangela Chicaroni de Mattos Oliveira, Rafael Espigolan, José Bento Sterman Ferraz, Tiago do Prado Paim   +5 more
wiley   +1 more source

Single‐Step Genomic Predictions for Growth and Carcass Traits in Nordic Charolais and Hereford Cattle

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In order to investigate the applicability and efficiency of genomic selection for growth and carcass traits in Nordic beef cattle, single‐step genomic BLUP (ssGBLUP) was applied in 4321 Charolais and 4532 Hereford animals with information on approximately 43,000 SNPs each.
Anahit Nazari‐Ghadikolaei, Freddy Fikse, Susanne Eriksson   +2 more
wiley   +1 more source