Results 41 to 50 of about 741 (144)

Estandarización de extracto de Maqui (Aristotelia chilensis) y su encapsulación en nanogeles de quitosano y nanosistemas basados en quenopodina

, 2023
El maqui es una baya reconocida por su riqueza en antioxidantes, particularmente por su alto contenido de compuestos polifenólicos, tales como ácidos fenólicos, flavonoides y antocianinas.
Andrade Ayala, Daniela Constanza
core   +1 more source

Flow chart outlining the elements of QbD (QTPP: Quality targeted product profile, CPPs: Critical process parameters, CQAs: Critical quality attributes, DOE: Design of experiments).

, 2018
Flow chart outlining the elements of QbD (QTPP: Quality targeted product profile, CPPs: Critical process parameters, CQAs: Critical quality attributes, DOE: Design of experiments).
Affiong Iyire (5921126), Afzal R. Mohammed (598394), Thomas J. Dennison (3070743), Ali Al-khattawi (598390), Eman Z. Dahmash (5921123), Hamad Al-Yami (5921129)   +5 more
core   +1 more source

Application of the quality by design (QbD) approach for the development of composition of extended-release tablets based on sodium 4,4’-(propanediamido)dibenzoate

Разработка и регистрация лекарственных средств
Introduction. Pharmaceutical development is a complex work, the main goal of which is to achieve the quality target product profile (QTPP). QTPP is formulated on the basis of a whole set of requirements for the drug, including pharmacopoeial, consumer ...
Yu. M. Kotsur, E. V. Flisyuk, I. A. Narcevich   +2 more
doaj   +1 more source

High‐throughput development and scale‐up of recombinant adeno‐associated virus 5 anion‐exchange chromatography for high‐purity capsid separation

Biotechnology Progress, EarlyView.
High‐throughput anion‐exchange chromatography process development enables scalable purification of high‐purity recombinant adeno‐associated virus capsids. Abstract Recombinant adeno‐associated virus (rAAV) production commonly yields a high proportion of empty and partially filled capsids, necessitating downstream purification to enrich full capsids ...
Kevin Vera, Ivan Gajic, Praveen Kusumanchi, Angela Andaluz, Gabrielle Dela Pena, Clifford A. Froelich, Elizabeth Higgins, Jennifer Johnston, Seyed Pouria Motevalian   +8 more
wiley   +1 more source

Integrating Nuclear Magnetic Resonance into Bioprocess Control of Clinical‐Grade Extracellular Vesicle Manufacturing

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
Nuclear magnetic resonance (NMR) in bioprocess design for the production of extracellular vesicles (EVs). NMR‐metabolomics enables real‐time bioprocess intelligence, bridging biological complexity with GMP rigor and accelerating the clinical translation of EV‐based therapies.
Santiago Roura, Núria Amigó, Joaquim Vives   +2 more
wiley   +1 more source

From Lab to Upscale—Boosting Formulation Performance through In Vitro Technologies

, 2020
Pre-stability studies carried out throughout the development of a diclofenac emulgel formulation have shown a clear decrease in the drug release rate.
Miranda, Vitorino, Cardoso, Veloso
core   +1 more source

Minimalist, bioinspired and sensorial emulsion based on a Ca2+ double cone vector system using Design of Experiment (DoE)

International Journal of Cosmetic Science, Volume 48, Issue 3, Page 489-499, June 2026.
Development of a biomimetic calcium‐based minimalist skin formulation using Design of Experiment (DoE) to correlate key ingredients' effect on the sensory and physico‐chemical properties of the emulsion. Abstract Objectives Innovation is considered a determining factor in the highly competitive environment of the cosmetic industry to introduce products
Marc Lavarde, Marjorie Lassalle, Solène Gouot, Ysaline Corroyer, Clara Marceau, Vincent Briffaut, Stéphane Poigny, Samar Issa   +7 more
wiley   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, Volume 2, Issue 1, Page 130-156, March 2026.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters

Pharmaceutics, 2020
Rivastigmine is a drug commonly used in the management of Alzheimer’s disease that shows bioavailability problems. To overcome this, the use of nanosystems, such as nanostructured lipid carriers (NLC), administered through alternative routes seems ...
Sara Cunha, Cláudia Pina Costa, Joana A. Loureiro, Jorge Alves, Andreia F. Peixoto, Ben Forbes, José Manuel Sousa Lobo, Ana Catarina Silva   +7 more
doaj   +1 more source

Evaluation of Formulation Parameters on Permeation of Ibuprofen from Topical Formulations Using Strat-M^® Membrane

Pharmaceutics, 2020
Topical drug delivery is an attractive alternative to conventional methods because of advantages such as non-invasive delivery, by-pass of first pass metabolism, and improved patient compliance.
Pradeep Kumar Bolla, Bradley A. Clark, Abhishek Juluri, Hanumanth Srikanth Cheruvu, Jwala Renukuntla   +4 more
doaj   +1 more source