Results 61 to 70 of about 741 (144)

QbD‐Based Development of Self‐Nanoemulsifying Drug Delivery System for Codelivery of Simvastatin and Ezetimibe With Enhanced In Vitro Dissolution

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
Simvastatin and ezetimibe are antihyperlipidemic agents that exhibit synergistic therapeutic effects but have poor aqueous solubility, resulting in low and variable oral bioavailability. This study aimed to develop an optimized self‐nanoemulsifying drug delivery system (SNEDDS) for the codelivery of simvastatin and ezetimibe using a quality‐by‐design ...
Sani Ega Priani, Anis Yohana Chaerunisaa, Gofarana Wilar, Iyan Sopyan, Mozhgan Afshari   +4 more
wiley   +1 more source

Combining DOE with an empirical approach to improve vaccine formulation development [PDF]

, 2016
Vaccine development and formulation is based upon understanding of the candidate’s target product profile, and leverages knowledge and experience in pharmaceutical products.
Livengood, Jill, Bushey, Melissa, Powell, Tim   +2 more
core   +1 more source

Vaccine process technology—A decade of progress

Biotechnology and Bioengineering, Volume 121, Issue 9, Page 2604-2635, September 2024.
Abstract In the past decade, new approaches to the discovery and development of vaccines have transformed the field. Advances during the COVID‐19 pandemic allowed the production of billions of vaccine doses per year using novel platforms such as messenger RNA and viral vectors.
Barry Buckland, Gautam Sanyal, Todd Ranheim, David Pollard, Jim A. Searles, Sue Behrens, Stefanie Pluschkell, Jessica Josefsberg, Christopher J. Roberts   +8 more
wiley   +1 more source

Step‐By‐Step Standardization of the Bottom‐Up Semi‐Automated Nanocrystallization of Pharmaceuticals: A Quality By Design and Design of Experiments Joint Approach

Small, Volume 20, Issue 25, June 19, 2024.
This article presents a breakthrough in bottom‐up nanocrystallization, improving the reproducibility, robustness, and potential scalability of the solvent–antisolvent methodology for pharmaceutical nanocrystals. This approach provides a risk‐, statistical‐, mathematical‐, and quality‐based protocol to fulfill the defined quality profile of ...
Luis Castillo Henríquez, Badr Bahloul, Khair Alhareth, Feras Oyoun, Markéta Frejková, Libor Kostka, Tomáš Etrych, Luc Kalshoven, Alain Guillaume, Nathalie Mignet, Yohann Corvis   +10 more
wiley   +1 more source

A-QbD-based green RP-HPLC method for estimation of rivaroxaban in pharmaceutical dosage forms

Discover Chemistry
This work reports the Analytical Quality by Design (AQbD) based green RP-HPLC method for Rivaroxaban, aimed at delivering a sustainable and robust analytical approach.
Yukta Vijay Kotecha, Dinesh Dattatray Rishipathak, Rakesh Uttamrao Shelke, Vijay Arjun Bagul, Anand Radheshyam Tiwari, Suryakant D. Bhosle   +5 more
doaj   +1 more source

QbD‐Based Fabrication of Biomimetic Hydroxyapatite Embedded Gelatin Nanoparticles for Localized Drug Delivery against Deteriorated Arthritic Joint Architecture

Macromolecular Bioscience, Volume 24, Issue 2, February 2024.
A research study is designed to fabricate Tofacitinib loaded nanohydroxyapatite embedded gelatin nanoparticles (Tofa‐nHA‐GLT NPs) to target Rheumatoid Arthritis (RA) and its related bone deformities. The result outcomes show a successful development of desired NPs, with optimal size, morphology, significant cellular uptake and biocompatibility with ...
Qurat Ul Ain, Mahira Zeeshan, Danish Mazhar, Ahmed Zeb, Iqra Afzal, Hameed Ullah, Hussain Ali, Abbas Rahdar, Ana M. Díez‐Pascual   +8 more
wiley   +1 more source

QbD green analytical procedure for the quantification of tolvaptan by utilizing stability indicating UHPLC method

BMC Chemistry
For the first time a new QbD-assisted green stability indicating ultra-high-performance liquid chromatography (UHPLC) method was developed and validated for quantifying Tolvaptan.
Shadab Anwar Hashmi, Pallavi Alegete
doaj   +1 more source

Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box–Behnken Design for Boosting Oral Bioavailability

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2024, Issue 1, 2024.
Purpose: The current study aimed to improve the oral bioavailability of tenofovir (TNF), an antihuman immunodeficiency viral (HIV) drug, by integrating it into solid lipid nanoparticles (SLNs), an emerging lipid formulation. Method: The suggested SLNs were generated utilizing the microemulsion process, using Compritol 888 ATO.
Sri Rekha M., Sangeetha S., Srinivas Mutalik   +2 more
wiley   +1 more source

Desarrollo de nuevas formulaciones de liberación controlada bajo un programa de calidad por diseño (QbD) [PDF]

, 2021
[ES] La finalidad de este trabajo ha sido desarrollar comprimidos matriciales recubiertos para la liberación en el colon de metronidazol bajo un programa de Calidad por Diseño (QbD).
Arévalo Pérez, Roberto
core  

QBD-BASED DEVELOPMENT OF ORODISPERSIBLE FILMS OF ANTIPSYCHOTIC DRUGS [PDF]

, 2022
This review provides an overview of the application of the Quality by Design (QbD) approach in the formulation and evaluation of the orodispersible films (ODFs) of antipsychotic drugs.
M. P., GOWRAV, S. K., MANOHAR, GOWDA, D. V.   +2 more
core   +1 more source