Results 151 to 160 of about 6,291 (282)

Model‐Based Systems Engineering in Space Applications: A Comprehensive Literature Review

open access: yesSystems Engineering, EarlyView.
ABSTRACT The growing complexity of space engineering is driving the demand to embrace the adoption of Model‐Based Systems Engineering (MBSE). Although the MBSE is well‐practiced in the space industry, the level of effort and need required to obtain the benefits of MBSE vastly differ across enterprises; this disparity presents a significant challenge to
Rehobot Bekele Buruso   +4 more
wiley   +1 more source

Building Collaboration Theory Across Education Science and Systems Engineering—The FINDUS Process for Collaboration

open access: yesSystems Engineering, EarlyView.
ABSTRACT Systems Engineering (SE) relies on industry–academia collaboration for much of its research. Such collaborations are frequently described valuable in practice. At the same time, there is a need to align between partners to maximize the value of collaboration through acknowledging and working with nuances between parties to share and develop ...
Johan Cederbladh, Simon Sjölund
wiley   +1 more source

The Embryonic Development of the Cotylean Polyclad Phrikoceros jannetae

open access: yesActa Zoologica, EarlyView.
ABSTRACT Polyclads exhibit distinct developmental modes ranging from direct to indirect development, with several transitional stages also recognised. The existence of an indirect developmental mode in polyclads with a planktonic life history stage in the form of a free‐swimming larva is unique among all free‐living flatworms and makes polyclads a ...
Mehrez Gammoudi   +6 more
wiley   +1 more source

JPEG: the quadruple object

open access: yes, 2013
The thesis, together with its practice-research works, presents an object-oriented perspective on the JPEG standard. Using the object-oriented philosophy of Graham Harman as a theoretical and also practical starting point, the thesis looks to provide ...
Caplan, Paul Lomax
core  

Contrasting effects of different molecular crowding environments on base‐pair opening/closing dynamics of DNA triplex structures

open access: yesThe FEBS Journal, EarlyView.
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto   +3 more
wiley   +1 more source

Genetic dissection reveals distinct contributions of the eS31 N‐terminal domain to translational accuracy in Saccharomyces cerevisiae

open access: yesThe FEBS Journal, EarlyView.
The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao   +3 more
wiley   +1 more source

Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes

open access: yesThe FEBS Journal, EarlyView.
Cold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Stefania Digiovanni   +5 more
wiley   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

open access: yesThe FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka   +10 more
wiley   +1 more source

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