Results 171 to 180 of about 4,909 (260)

Chemotaxis to plant defense compounds in phytopathogens. [PDF]

PLoS Pathog
Genova R, Holmes A, Cano-Muñoz M, Ishihara A, Ube N, Nomura T, Gavira JA, Matilla MA, Krell T.   +8 more
europepmc   +1 more source

Candidate Right Locus Coeruleus‐Centered Symptom Pathways in Young Major Depressive Disorder: A Multimodal Magnetic Resonance Imaging Study

Human Brain Mapping, Volume 47, Issue 12, August 15, 2026.
In young major depressive disorder, substantia nigra and locus coeruleus qMRI phenotypes were linked to functional network organization and depressive severity through right locus coeruleus‐centered connectivity pathways. ABSTRACT Major depressive disorder (MDD) involves network‐level abnormalities that may reflect dysfunction in catecholaminergic ...
Zesong Yuan, Jing Wang, Danian Li, Baohua Cheng, Yingpeng Kuang, Rongyu Zhang, Nana Luo, Shijun Qiu, Yongsheng Chen, Yujie Liu   +9 more
wiley   +1 more source

Structural mechanism of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity. [PDF]

Commun Biol
Jiang J, Panda AK, Natarajan K, Lei H, Sharma S, Boyd LF, Towler RR, Chempati S, Ahmad J, Morton AJ, Lang ZC, Sun Y, Sgourakis N, Meier-Schellersheim M, Huang RK, Shevach EM, Margulies DH.   +16 more
europepmc   +1 more source

Cuprous Ions Binding to Cytosine and Guanine Oligonucleotides

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Using a comprehensive set of nucleic acid‐related molecules, from individual nucleobases to oligonucleotides, we demonstrate the selective binding of Cu+ to cytosine‐containing oligonucleotides. Contrary to guanine‐containing oligonucleotides, cytosine‐rich oligonucleotides form a Cu+‐complex with a clear near‐UV signature and are able to stop redox ...
Joana Pereira, Mathilde Brachet, Philippe Barthélémy, Bruno Alies   +3 more
wiley   +1 more source

Fine-Tuning of the Neuropeptide Y1 G Protein-Coupled Receptor by the Tryptophan^6.48 "Toggle Switch". [PDF]

J Am Chem Soc
Voitel M, Pankonin M, Vogel A, Leitner K, Kaiser A, Huster D, Hildebrand PW, Smith AA.   +7 more
europepmc   +1 more source

Exploration of Nirmatrelvir Derivatives as Optimized SARS‐CoV‐2 Antivirals

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Structure‐guided optimization of nirmatrelvir identifies aldehyde and dichloroacetamide warheads and a potency‐enhancing S4 thioamide. Crystal structures reveal an S2 rearrangement extending toward Cys44, suggesting a new covalent‐design opportunity.
Yugendar R. Alugubelli, Veerabhadra R. Vulupala, Kai S. Yang, Kaustav Khatua, Lauren R. Blankenship, Sathish Kumar, Demonta Coleman, Xuejiao Guo, Zhi Zachery Geng, Chia‐Chuan D. Cho, Banumathi Sankaran, Benjamin W. Neuman, Shiqing Xu, Wenshe Ray Liu   +13 more
wiley   +1 more source

Viral pathogens in the etiology of acute respiratory infections in Bulgaria during the 2024-2025 season and genetic diversity of circulating influenza viruses. [PDF]

Front Microbiol
Korsun N, Trifonova I, Pavlova D, Grigorova I, Uzunova Y, Ivanov I, Ivanov D, Velikov P, Voleva S, Christova I.   +9 more
europepmc   +1 more source

Cooperative reversible assembly in triply interlocked Al₆L₄ and Ga₆L₄ cages. [PDF]

Chem Sci
Izquierdo I, Martínez-Castro L, Ujaque G, Martínez-Martínez AJ.   +3 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, Volume 600, Issue 15, Page 2094-2107, August 2026.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Combined R2R3-MYB transcription factor mutants reveal the regulatory structure of the Arabidopsis thaliana flavonoid biosynthesis pathway. [PDF]

Planta
Sielmann LM, Denecke T, Weisshaar B, Stracke R.   +3 more
europepmc   +1 more source