Results 161 to 170 of about 129,304 (280)

Genetic dissection reveals distinct contributions of the eS31 N‐terminal domain to translational accuracy in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao, Hiroshi Otsuka, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Dynamic helical poly[4]helicene nanoribbon. [PDF]

Nat Commun
Ikai T, Inagaki H, Oki K, Yoshida M, Pirillo J, Hijikata Y, Yashima E.   +6 more
europepmc   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

A dual A-to-Y and G-to-Y base editor and a four-base concurrent hypermutator in mammalian cells. [PDF]

Nat Commun
Zhao N, Olajide JS, Guan Z, Huang J, Zou X, Ou F, Lin J, Tao T, Zhou T, Gao Z, Ren Z, Shi X, Huang X, Wang G.   +13 more
europepmc   +1 more source

Crystal structure and biochemical analysis of the polyester‐degrading carboxylesterase SM0281 from the symbiotic legume‐associated rhizobacterium Sinorhizobium (Ensifer) meliloti

The FEBS Journal, EarlyView.
The microbial degradation of synthetic polyesters such as polyethylene terephthalate (PET) is mediated by diverse α/β‐hydrolases, many of which remain poorly characterized. In this study, we investigated the α/β‐hydrolase SM0281 from Sinorhizobium meliloti and found that it exhibits robust carboxylesterase and polyesterase activities toward PET, PCL ...
Sofia Lemak, Anna N. Khusnutdinova, Peter J. Stogios, Elena Evdokimova, Alexei Savchenko, Peter N. Golyshin, Elizabeth A. Edwards, Alexander F. Yakunin   +7 more
wiley   +1 more source

PP2A regulates shade avoidance response by dephosphorylating phytochrome-interacting factor 7 in Arabidopsis. [PDF]

Plant J
Cai X, Mitra O, Gustamante A, Tang W, Sun Y, Huq E.   +5 more
europepmc   +1 more source

Capture Probability and Effects of Bait Type on Learning Behavior in an Unexploited Population of Northern Pike (Esox lucius)

Fisheries Management and Ecology, EarlyView.
ABSTRACT Changes in angling response were studied over a period of three years in a natural, previously unfished population of northern pike. Standardized angling sessions took place during two weeks in spring and autumn with three bait types: bright‐ and natural‐colored soft plastic baits and a dead baitfish.
Jorrit Lucas, Albert Ros, Juergen Geist, Alexander Brinker   +3 more
wiley   +1 more source

N-Terminal Actin-Binding Site of Lmod2 Promotes Controlled Pointed End Elongation. [PDF]

Circ Res
Larrinaga TM, Smith GE, Tolkatchev D, Rast TJ, Bunch TA, Colson BA, Pappas CT, Kostyukova AS, Gregorio CC.   +8 more
europepmc   +1 more source

C‐type cyclin CycC1;1 delays leaf senescence by interacting with and inhibiting MYC2 in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The C‐type cyclin CycC1;1 interacts with MYC2 and MED25 to block their association and RNA polymerase II recruitment, thereby repressing senescence‐associated gene expression and delaying leaf senescence in Arabidopsis. Unlike jasmonic acid‐inducible JAZ repressors, CycC1;1 operates independently of jasmonic acid signaling, representing an ...
Cai‐Yi Liao, Xiao‐Li Huang, Lin Li, Guo‐Mao Liu, Kai‐Kai Lu, Hong Yang, Song‐Qi Li, Peng‐Wei Jing, Ru‐Feng Song, Wen‐Cheng Liu   +9 more
wiley   +1 more source