Results 71 to 80 of about 39,529 (294)

Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3’ regulatory regions and its conservation in mammals [PDF]

, 2016
Regulatory regions in the genome can act through a variety of mechanisms that range from the occurrence of histone modifications to the presence of protein-binding loci for self-annealing sequences.
Cacchione, Stefano, Cicconi, Alessandro, D'Addabbo, Pietro, Frezza, Domenico, Gargioli, Cesare, Giambra, Vincenzo, Kelly, Geoffrey, Micheli, Emanuela, Poma, Anna, Sette, Marco   +9 more
core   +2 more sources

DNA and RNA Quadruplex ligands [PDF]

Nucleic Acids Symposium Series, 2008
Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes.
De Cian, Anne, Gros, Julien, Guédin, Aurore, Haddi, Meriem, Lyonnais, Sébastien, Guittat, Lionel, Riou, Jean-François, Trentesaux, Chantal, Sacca, Barbara, Lacroix, Laurent, Alberti, Patrizia, Mergny, Jean-Louis   +11 more
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids [PDF]

, 2017
open5noBACKGROUND: G-quadruplexes (G4s) are four-stranded nucleic acid structures that form in G-rich sequences. Nucleolin (NCL) is a cellular protein reported for its functions upon G4 recognition, such as induction of neurodegenerative diseases, tumor
Elena Tosoni, Manlio Palumbo, Matteo Nadai, Sara Lago, Sara N. Richter   +4 more
core   +1 more source

Polyelectrolyte effects in G-quadruplexes [PDF]

Biophysical Chemistry, 2013
The role of counterion condensation as a dominant force governing the stability of DNA duplexes and triplexes is well established. In contrast, the effect of counterion condensation on the stability of G-quadrupex conformations is poorly understood. Unlike other ordered nucleic acid structures, G-quadruplexes exhibit a specific binding of counterions ...
Kim, Byul, Shek, Yuen L., Chalikian, Tigran V.   +2 more
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

DNA Base Excision Repair Intermediates Influence Duplex–Quadruplex Equilibrium

Molecules, 2023
Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex.
Mark L. Sowers, James W. Conrad, Bruce Chang-Gu, Ellie Cherryhomes, Linda C. Hackfeld, Lawrence C. Sowers   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Aminoglycosylation can enhance the G-quadruplex binding activity of epigallocatechin. [PDF]

PLoS ONE, 2013
With the aim of enhancing G-quadruplex binding activity, two new glucosaminosides (16, 18) of penta-methylated epigallocatechin were synthesized by chemical glycosylation.
Li-Ping Bai, Hing-Man Ho, Dik-Lung Ma, Hui Yang, Wai-Chung Fu, Zhi-Hong Jiang   +5 more
doaj   +1 more source

Synthesis of copper (II) porphyrin complexes and their interaction with c-myc G-quadruplex DNA

Journal of Holistic Integrative Pharmacy, 2021
Objective: To synthesize copper (II) porphyrin complexes and study their interactions with c-myc G-quadruplex DNA. Methods: The 5-p-hydroxyphenyl-10, 15, 20-tris (p-methoxyphenyl) copper (II) porphyrin complex [p-HTMOPPCu (II)] was synthesized by the ...
Kunxian YANG, Jiashu CHEN, Bingbing ZHAI, Weiming CHEN, Huanglan YANG, Yufen XIAO, Juping WANG, Wenjie MEI   +7 more
doaj   +1 more source