Results 81 to 90 of about 29,743 (315)
DNA secondary structures: stability and function of G-quadruplex structures
Nature reviews genetics, 2012 In addition to the canonical double helix, DNA can fold into various other inter- and intramolecular secondary structures. Although many such structures were long thought to be in vitro artefacts, bioinformatics demonstrates that DNA sequences capable of
Matthew L. Bochman +2 more
semanticscholar +1 more source
Roles of the RGG Domain and RNA Recognition Motif of Nucleolin in G-Quadruplex Stabilization
ACS Omega, 2020 G-quadruplexes have important biologic functions that are regulated by G-quadruplex-binding proteins. In particular, G-quadruplex structures are folded or unfolded by their binding proteins and affect transcription and other biologic functions.
Tatsuki Masuzawa, T. Oyoshi
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang +10 more
wiley +1 more source
Molecules, 2019 G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or ...
Zhi-Yin Sun +4 more
semanticscholar +1 more source
Advanced Engineering Materials, EarlyView.A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares +3 more
wiley +1 more source
Quadruplex nucleic acids as targets for anticancer therapeutics
, 2017 Quadruplex nucleic acids — helical four-stranded structures known to form from guanine-rich nucleic acid sequences through Hoogsteen-type hydrogen bonding — were once just laboratory curiosities.
S. Neidle
semanticscholar +1 more source
Feasibility of Nitrogen as a Carrier Gas for Inconel Cold Spray in Hydropower Application
Advanced Engineering Materials, EarlyView.N2, despite being nearly two orders of magnitude cheaper than He, is a feasible carrier gas for cold spray Inconel coatings in hydropower repair applications when higher gas temperature and pressure are used. Reducing powder size significantly improved cavitation resistance, while the addition of fine chromium carbide particles further enhanced erosion
Tianhao Wang +4 more
wiley +1 more source
Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.
PLoS ONE, 2014 Four-stranded G-quadruplex DNA secondary structures have recently been visualized in the nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody, can be used to stain DNA G-quadruplex structures in patient-derived tissues
Giulia Biffi +4 more
doaj +1 more source
Exclusion of RNA-binding domains from G-quadruplex condensates by G-quadruplex ligands [PDF]
RSC Chemical BiologyBiomolecular liquid–liquid phase separation, which forms droplets in living cells, plays a crucial role in the regulation of gene expression. Dysfunction of liquid–liquid phase separation leads to aberrant aggregates that sequester RNA-binding proteins ...
Yoshiki Hashimoto +8 more
doaj +1 more source
bioRxiv, 2019 The sorting of RNA molecules to distinct subcellular locations facilitates the activity of spatially restricted processes through local protein synthesis.
Raeann Goering +7 more
semanticscholar +1 more source