Results 81 to 90 of about 39,952 (313)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition

Molecules, 2020
G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation.
Tingting Zou, Shinobu Sato, Rui Yasukawa, Ryusuke Takeuchi, Shunsuke Ozaki, Satoshi Fujii, Shigeori Takenaka   +6 more
doaj   +1 more source

IFI16 Preferentially Binds to DNA with Quadruplex Structure and Enhances DNA Quadruplex Formation. [PDF]

PLoS ONE, 2016
Interferon-inducible protein 16 (IFI16) is a member of the HIN-200 protein family, containing two HIN domains and one PYRIN domain. IFI16 acts as a sensor of viral and bacterial DNA and is important for innate immune responses.
Lucia Hároníková, Jan Coufal, Iva Kejnovská, Eva B Jagelská, Miroslav Fojta, Petra Dvořáková, Petr Muller, Borivoj Vojtesek, Václav Brázda   +8 more
doaj   +1 more source

PrimPol is required for replicative tolerance of G quadruplexes in vertebrate cells [PDF]

, 2016
G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epigenetic instability.
Bailey, Laura J, Doherty, Aidan J, Guilbaud, Guillaume, Guilliam, Thomas A, Jozwiakowski, Stanislaw K, Romanello, Marina, Sale, Julian E, Schiavone, Davide   +7 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines

BMC Research Notes, 2012
Background Guanosine rich sequences capable of forming G-quadruplex (G4) motifs are enriched near the gene transcription start site (TSS) in the human genome.
Halder Rashi, Riou Jean-Francois, Teulade-Fichou Marie-Paule, Frickey Tancred, Hartig Jörg S   +4 more
doaj   +1 more source

Design of surface-active artificial enzyme particles to stabilize Pickering emulsions for high-performance biphasic biocatalysis [PDF]

, 2015
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Surface-active artificial enzymes (SAEs) are designed and constructed by a general and novel strategy.
Baciocchi, Binks, Bonomi, Chen, Chen, Crossley, Dewey, Diez-Castellnou, Gao, Jiang, Kapil, Kosif, Köhler, Li, Li, Lin, Liu, Liu, Mondloch, Nanda, Natalio, Neverov, Pengo, Pera-Titus, Silverman, Smith, Song, Sun, Tonga, Vernekar, Wang, Wang, Wang, Wiese, Wu, Yang, Zapata, Zaramella, Zhang, Zhou   +39 more
core   +1 more source

The Tale of the Residual Tail: Insights From Continuous Intracranial Monitoring From Post‐Hippocampectomy Dynamics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Subtotal hippocampal resection can leave residual hippocampal tissue, yet the immediate postoperative electrophysiologic evolution of such remnants is unknown. We describe a patient with drug‐resistant temporal lobe epilepsy in whom a hippocampal remnant was continuously monitored using a responsive neurostimulator (RNS) following subtotal ...
Patrick Hartnett, Syeda Amrah Hashmi, Amaan Qureshi, Heather Spader, Shayan Moosa, Ifrah Zawar   +5 more
wiley   +1 more source

Hydrogen peroxide thermochemical oscillator as driver for primordial RNA replication

, 2014
This paper presents and tests a previously unrecognised mechanism for driving a replicating molecular system on the prebiotic earth. It is proposed that cell-free RNA replication in the primordial soup may have been driven by self-sustained oscillatory ...
Ball, Rowena, Brindley, John
core   +1 more source