Results 141 to 150 of about 3,381,508 (304)

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, EarlyView.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Abrupt structural transition in exotic molybdenum isotopes unveils an isospin-symmetric island of inversion. [PDF]

Nat Commun
Ha J, Recchia F, Lenzi SM, Iwasaki H, Dao DD, Nowacki F, Revel A, Aguilera P, de Angelis G, Ash J, Bazin D, Bentley MA, Biswas S, Carollo S, Cortes ML, Elder R, Escudeiro R, Farris P, Gade A, Ginter T, Grinder M, Li J, Napoli DR, Noji S, Pereira J, Pigliapoco S, Pompermaier A, Poves A, Rezynkina K, Sanchez A, Wadsworth R, Weisshaar D.   +31 more
europepmc   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Hyperfine spectroscopy of optical-cycling transitions in singly ionized thulium. [PDF]

Sci Rep
Müller P, Tretiakov A, Younes A, Halawani N, C Campbell W, Hamilton P.   +5 more
europepmc   +1 more source

Rotational Detection of the Missing Conformers of 2-Chloropropionic Acid. [PDF]

J Phys Chem A
Sun F, Maris A, Evangelisti L, Song W, Melandri S, Morán JR, Calabrese C, Lesarri A, Grabow JU.   +8 more
europepmc   +1 more source

Anomalous Spin-Optical Helical Effect in Ti-Based Kagome Metal. [PDF]

Adv Mater
Mazzola F, Brzezicki W, Bigi C, Consiglio A, D'Onofrio LJ, Mercaldo MT, Kłosiński A, Bertran F, Le Fèvre P, Clark OJ, Edmonds MT, Tuniz M, De Vita A, Polewczyk V, Jacobsen JB, Jacobsen H, Miwa JA, Wells JW, Jana A, Vobornik I, Fujii J, Mignani N, Samani NT, Crepaldi A, Sangiovanni G, Kataria A, Morresi T, Sanna S, Bonfá P, Ortiz BR, Pokharel G, Wilson SD, Sante DD, Ortix C, Cuoco M.   +34 more
europepmc   +1 more source

Absorption enhancement of an electric quadrupole transition of cesium atoms in an evanescent field.

Physical Review Letters, 2004
S. Tojo, M. Hasuo, T. Fujimoto
semanticscholar   +1 more source

Fine-structure constant sensitivity of the Th-229 nuclear clock transition. [PDF]

Nat Commun
Beeks K, Kazakov GA, Schaden F, Morawetz I, Toscani De Col L, Riebner T, Bartokos M, Sikorsky T, Schumm T, Zhang C, Ooi T, Higgins JS, Doyle JF, Ye J, Safronova MS.   +14 more
europepmc   +1 more source

Compositional Characterization, Quality Parameters, and Physicochemical and Bioactive Properties of Pequi (Caryocar brasiliense) Oils From Xingu and Cerrado in Mato Grosso, Brazil

Journal of the American Oil Chemists' Society, EarlyView.
Cerrado oil is richer in MUFA and antioxidant compounds, while Xingu oil shows higher SFA and enhanced oxidative stability, reinforcing the potential of pequi oil as a sustainable bioactive ingredient. ABSTRACT Pequi (Caryocar brasiliense) is a native fruit widely distributed in Brazilian biomes, specially in Cerrado, known for its high oil yield and ...
Dhayna O. Sobral, Patrícia T. Souza, Gabriel S. L. Pereira, Sara Fraga, Maria E. O. Carvalho, Antonio J. A. Meirelles, Eduardo A. C. Batista, Klicia A. Sampaio, Guilherme J. Maximo   +8 more
wiley   +1 more source