Results 61 to 70 of about 1,730,968 (259)

Association Between Sedentary Time and Quality of Life From the Osteoarthritis Initiative: Who Might Benefit Most From Treatment? [PDF]

, 2017
Objective To investigate the relationship between sedentary behavior and quality-adjusted life years (QALYs) among participants in the Osteoarthritis Initiative. Design Longitudinal, observational design.
Chang, Rowland W., Dunlop, Dorothy D., Ehrlich-Jones, Linda S., Lee, Jungwha, Pellegrini, Christine A., Pinto, Daniel, Semanik, Pamela A., Song, Jing   +7 more
core   +1 more source

Economic evaluation of laparoscopic surgery for colorectal cancer [PDF]

, 2007
Objectives: To assess the cost-effectiveness of laparoscopic surgery compared with open surgery for the treatment of colorectal cancer. Methods: A Markov model was developed to model cost-effectiveness over 25 years.
Aberdeen Health Technology Assessment Group, De Verteuil, Robyn, Hernández, Rodolfo Andrés, Vale, Luke David   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Impact of Inactivated Influenza Vaccination on Health‐Related Quality of Life Among Japanese Healthcare Workers

Immunity, Inflammation and Disease
Background Influenza vaccinations are recommended for healthcare workers (HCWs). Quantification of the personal risks of vaccination compared to vaccine benefits can help guide more accurate benefit‐risk assessment and cost‐effectiveness analysis of ...
Taito Kitano, Sayaka Yoshida
doaj   +1 more source

Overcoming hurdles: measurement of health-related outcomes associated with national level medicines usage in Ireland

Drugs in Context, 2020
Public discourse on medicine provision predominantly focuses on overall expenditure. However, current literature suggests measurement of alternative indicators can provide a method to benchmark or ameliorate medicine provision.
Gary L O’Brien, Muireann McAlister, Stephen Byrne, James Gallagher   +3 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Cost-Utility Analysis of Colorectal Cancer Screening Starting at Age 45 Compared to Age 50 in Colombia

Revista Colombiana de Gastroenterología
Background: Colorectal cancer (CRC) is among the four cancers with the highest incidence and mortality in Colombia. CRC screening is currently recommended in national guidelines starting at age 50.
Gerardo Andrés Puentes Leal, Marcela Pérez Rodríguez , Esperanza Peña Torres   +2 more
doaj   +1 more source

A Decision Rule for Transplanting Non-Cadaveric Organs [PDF]

This paper conceptually analyzes the minimum probability of success required for transplanting non-cadaveric organs, its relationship with the initial, and possible rates of change in the, quality-adjusted life-years of the recipient and donor and its ...
Levy, Amnon
core  

To be screened or not to be screened Modeling the consequences of PSA screening for the individual [PDF]

, 2012
Background:Screening with prostate-specific antigen (PSA) can reduce prostate cancer mortality, but may advance diagnosis and treatment in time and lead to overdetection and overtreatment.
Bangma, C.H. (Chris), Draisma, G. (Gerrit), Heijnsdijk, E.A.M. (Eveline), Hugosson, J. (Jonas), Koning, H.J. (Harry) de, Wever, E.M. (Elisabeth)   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source