Results 71 to 80 of about 8,759,542 (335)

Methodological Approaches to Validation of Therapeutic Recombinant Proteins Production Based on the Quality by Design Concept

Биопрепараты: Профилактика, диагностика, лечение, 2018
Validation of production processes based on the Quality by Design (QbD) principles calls for thorough scientific understanding of the processes and enhancement of their stability by implementation of new technologies.
N. V. Stratonova, A. S. Lisov, A. N. Morozov, D. V. Tyupa, R. A. Khamitov   +4 more
doaj   +1 more source

Quality measures for ETL processes: from goals to implementation [PDF]

, 2016
Extraction transformation loading (ETL) processes play an increasingly important role for the support of modern business operations. These business processes are centred around artifacts with high variability and diverse lifecycles, which correspond to ...
Akkaoui, Batini, Bellatreche, Brereton, Bresciani, Chung, Dustdar, Frakes, Gill, Giorgini, Horkoff, Horkoff, Horkoff, Jarke, Jarke, Jogalekar, Kitchenham, Lamsweerde, Leite, Naumann, Romero, Simitsis, Sánchez-González, Thiele, Yu   +24 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Important Aspects of the Design of Experiments and Data Treatment in the Analytical Quality by Design Framework for Chromatographic Method Development

Molecules
In the analytical quality by design (AQbD) framework, the design of experiments (DOE) plays a very important role, as it provides information about how experimental input variables influence critical method attributes.
Bianca F. G. Passerine, Márcia C. Breitkreitz   +1 more
doaj   +1 more source

Implementation and evaluation of simultaneous video-electroencephalography and functional magnetic resonance imaging [PDF]

, 2010
The objective of this study was to demonstrate that the addition of simultaneous and synchronised video to electroencephalography (EEG)-correlated functional magnetic resonance imaging (fMRI) could increase recorded information without data quality ...
Carmichael, D.W., Chaudhary, U.J., Duncan, J.S., Gasston, D., Kokkinos, V., Lemieux, L., Rodionov, R.   +6 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Quality By Design Approach For Longitudinal Quality Attributes [PDF]

Journal of Biopharmaceutical Statistics, 2014
The concept of quality by design (QbD) as published in ICH-Q8 is currently one of the most recurrent topics in the pharmaceutical literature. This guideline recommends the use of information and prior knowledge gathered during pharmaceutical development studies to provide a scientific rationale for the manufacturing process of a product and provide ...
Lebrun, Pierre, Giacoletti, Katherine, Scherder, Tara, Rozet, Eric, Boulanger, Bruno   +4 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Risperidone-Loaded Nasal Thermosensitive Polymeric Micelles: Quality by Design-Based Formulation Study

Pharmaceutics
The current research aims to develop thermosensitive polymeric micelles loaded with risperidone for nasal administration, emphasizing the added benefits of their thermosensitive behavior under nasal conditions.
Bence Sipos, Gábor Katona, Ildikó Csóka   +2 more
doaj   +1 more source

Nitrogen, Phosphorus, and Suspended Solids Concentrations in Tributaries to the Great Bay Estuary Watershed in 2014 [PDF]

, 2014
Nitrogen, phosphorus, and sediment loads to the Great Bay Estuary are a constant concern. The Piscataqua Region Estuaries Partnership (PREP) calculates the nitrogen load from tributaries to the Great Bay Estuary for its State of Our Estuaries reports ...
Wood, Matthew A.
core   +2 more sources