Results 81 to 90 of about 10,211,998 (304)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Women Suffered More Than Men Both During and After the COVID‐19 Pandemic—A Cross‐Sectional Study Among 29,079 Patients With Type 2 Diabetes

open access: yesEndocrinology, Diabetes & Metabolism
Objective To investigate the gender differences and the disparities between infected and noninfected patients with type 2 diabetes (T2D) regarding patient‐reported experiences during the COVID‐19 pandemic in Norway.
Grethe Åstrøm Ueland   +6 more
doaj   +1 more source

Social care division/quality improvement division QI programme newsletter September 2016

open access: yes, 2016
Programme newsletter for the social care division/quality improvement division quality improvement ...
National Quality Improvement Team
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of electric field frequency on phytoremediation efficiency and properties of Cd-contaminated soil

open access: yesEnvironmental Sciences Europe
Electrochemical-phytoextraction is considered as an integrated technology for removal of Cd in contaminated soil. However, there is a lack of systematic studies on the how electric field frequency plant Cd enrichment and soil microbial properties, which ...
Xiaolan Xu   +6 more
doaj   +1 more source

Quality and Patient Safety Division Annual Report 2014

open access: yes, 2015
A work plan is developed on an annual basis to support the quality and patient safety objectives in the National Service Plan. This report reviews the work completed in 2014 in delivery of the 2013 plan.
Quality Improvement Division
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Identification and molecular marker analysis of PHS resistance of high generation wheat materials

open access: yesScientific Reports
Pre-harvest sprouting (PHS) of wheat will significantly reduce the yield and quality of wheat and threaten the safety of wheat production in China. Screening and utilization of resistant germplasm and functional molecular markers is the fundamental way ...
Heng Zhou   +5 more
doaj   +1 more source

Preventing Blood Clots in Hospitals: Improvement Collaborative Report National Recommendations and Improvement Toolkit

open access: yes, 2018
This report shares learning from the collaborative, including which factors contributed to high levels of appropriate prophylaxis and to improvement. There was a higher level of appropriateness observed in orthopaedic and post-partum patients than in ...
National Medication Safety Improvement Programme
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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