Results 121 to 130 of about 687,925 (260)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Biomedical engineer density per hospital bed: A medical device quality indicator for Mexican Healthcare System. [PDF]

PLoS One
Ayala LG, Blas NA, Navor Galeana NP.
europepmc   +1 more source

The impact of unplanned 30-day readmission as a quality indicator in pediatric surgery. [PDF]

Front Surg, 2023
Ellul S, Shoukry M.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Early Mobilization Compliance as a Quality Indicator After Hip Fracture Surgery: An Observational Study. [PDF]

J Clin Med
Endara-Tello NE, Batalla-Pascua M, Córdoba-Ortega S, Álvarez-Villarreal M, García-Sánchez FJ.   +4 more
europepmc   +1 more source

Management control for quality in a hospitality business using ARP curves and the multivariate geometric indicator - Control de gestión para la calidad en una empresa hotelera con curvas ARP y el indicador geométrico multivariante

Introducción / Objetivo: este estudio tiene como objetivo evaluar la calidad del servicio en una empresa hotelera que opera con tres líneas de atención: preferencial, estándar y básica, bajo condiciones cambiantes.
Tomás José Fontalvo Herrera, Fabio Mejía Zambrano, Juan José Tous Ferrigno   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Development of a quality indicator set for day hospices in Germany - a multi-stage, quality-assured review of German guidelines and quality indicator sets. [PDF]

BMC Palliat Care
Kaiser U, Vehling-Kaiser U, Hoffmann A, Kaiser F, Rechenmacher M, Kaiser E, Chalupper R, Fiedler M, Kaiser F.   +8 more
europepmc   +1 more source

Quality and safety in residential aged care: an evaluation of a national quality indicator programme. [PDF]

Intern Med J, 2023
Inacio MC, Eshetie TC, Caughey GE, Whitehead C, Westbrook J, Gray L, Hibbert P, Beattie E, Braithwaite J, Cameron ID, Crotty M, Wesselingh S.   +11 more
europepmc   +1 more source