Results 131 to 140 of about 7,863,465 (307)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Board's Role in Improving Quality and Safety - Guidance and Resources [PDF]
, 2017 There are a number of key documents and resources applicable to boards and executives within healthcare in Ireland. This guidance builds on existing documentation and provides a central repository of international and national perspectives on the board’s
Quality Improvement Division
core
Duration of immunity (protection from reinfection) following SARSCoV-2 infection [v8.0]
, 2021 The Health Information and Quality Authority (HIQA) has developed a series of evidence syntheses to inform advice from HIQA to the National Public Health Emergency Team (NPHET). The advice takes into account expert interpretation of the evidence by HIQA’
Health Information and Quality Authority (HIQA)
core
DiagnosticsBackground: Quality indicators (QIs) are used to standardize care and improve outcomes in patients with pulmonary arterial hypertension (PAH). It is important that QIs are validated within specific healthcare contexts.
Yuichi Tamura +10 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Quality Improvement Division Annual Report 2016
, 2017 This report provides a high level overview of work completed by the Quality Improvement Division (QID) in 2016. In 2016 QID focused on developing and articulating the Framework for Improving quality that linked together the areas of work in Quality ...
Quality Improvement Division
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Quality Improvement Division Operational Plan 2017
, 2017 The Quality Improvement Division provides advice and support quality improvement projects and initiatives. We do this by partnering with frontline services however the implementation of these programmes remains with the leadership of frontline ...
Quality Improvement Division
core
Investigation of Electromagnetic Gauges for Determining In-Place HMA Density, 2007 [PDF]
, 2007 Density is an important component of hot-mix asphalt (HMA) pavement quality and long-term performance. Insufficient density of an in-place HMA pavement is the most frequently cited construction-related performance problem.
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source