Results 101 to 110 of about 353,246 (310)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Quality indicators for palliative care: update of a systematic review

, 2013
Context. In 2007, a systematic review revealed a number of quality indicators referring mostly to palliative care outcomes and processes. Psychosocial and spiritual aspects were scarcely represented. Most publications lacked a detailed description of the
Francke, A.L., Claessen, Susanne JJ, Deliens, L., Leemans, K., Claessen, S.J.J., Pasman, H.R.W., Pasman, H Roeline W, Roo, M.L. de, Deliens, Luc, ?, ?, Cohen, J., Leemans, Kathleen, De Roo, M.L.A., Cohen, Joachim, Francke, Anneke L, De Roo, Maaike L, Claessen, Susanne J J   +16 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Developing Iranian primary health care quality framework: a national study

BMC Public Health, 2019
Background Providing comprehensive and high-quality services is one of the most important goals of the health systems and a basic principle for Universal Health Coverage (UHC).
Ramin Rezapour, Jafar Sadegh Tabrizi, Mostafa Farahbakhsh, Mohammad Saadati, Hossein Mashhadi Abdolahi   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

An Environmental Scan of Canadian Quality Metrics for Patients on In-Center Hemodialysis

Canadian Journal of Kidney Health and Disease, 2020
Background: Quality metrics or indicators help guide quality improvement work by reporting on measurable aspects of health care upon which improvement efforts can focus.
Daniel Blum, Alison Thomas, Claire Harris, Jay Hingwala, William Beaubien-Souligny, Samuel A. Silver   +5 more
doaj   +1 more source

Patient-Centred Care: Improving Quality and Safety by Focusing Care on Patients and Consumers

, 2011
Patient-centred care is health care that is respectful of, and responsive to, the preferences, needs and values of patients and consumers. The widely accepted dimensions of patient-centred care are respect, emotional support, physical comfort ...
Dunbar, Nicola, Luxford, Karen, Poole, Naomi, Piper, Donella   +3 more
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Healthy Futures—Aboriginal Community Controlled Health Services: report card [PDF]

, 2015
During 2012-13, Aboriginal Community Controlled Health Services saw just over 250,000 Indigenous clients. This report shows increases in the proportion of clients receiving appropriate processes of care for ten of the 16 primary health care indicators ...
Australian Institute of Health and Welfare
core