Results 121 to 130 of about 20,259,607 (299)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Quality indicators for deceased organ and tissue donation for transplantation: a scoping review protocol

Systematic Reviews
Background The global shortage of organs and tissues highlights the need to strengthen and monitor the quality of deceased donor programs. Evaluating each stage of this process using quality-sensitive indicators is essential to ensure transparency ...
Rafael Rodrigo da Silva Pimentel, Daisy Maria Rizatto Tronchin, Marcelo José dos Santos, Maristela Santini Martins, Ágata Nunes Brito, Fabiana Lopes Pereira Santana   +5 more
doaj   +1 more source

Integral indicators of the quality of medical care – the way to build a high-quality health care system of Ukraine and the implementation of the best global practices for evaluating the effectiveness of health care technologies

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. About 60% of deaths from treatable conditions are caused by poor health care, while the remaining deaths result from failure to use the health care system. High-quality health systems can prevent 2.5 million deaths from cardiovascular disease,
Hladkykh F.V.
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

[Health care model and quality indicators: perceptions of primary health care professionals].

Cadernos de saude publica, 2011
This study aimed to verify the adequacy of family health teams according to the quality standards set by the Brazilian Ministry of Health and the correlation with health care activities, according to the health professionals themselves. The Evaluation for Quality Improvement (EQI) instrument was used in joint interviews with physicians, nurses, and ...
José Mendes da, Silva, Antônio Prates, Caldeira   +1 more
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Patient experiences with interdisciplinary treatment for substance dependence: an assessment of quality indicators based on two national surveys in Norway

Patient Preference and Adherence, 2019
Mona Haugum,1,2 Hilde Hestad Iversen,1 Jon Helgeland,1 Anne Karin Lindahl,2,3 Oyvind Bjertnaes11Division of Health Services, Norwegian Institute of Public Health, Oslo, Norway; 2Department of Health Management and Health Economics, Institute of Health ...
Haugum M, Iversen HH, Helgeland J, Lindahl AK, Bjertnaes O   +4 more
doaj  

Quality indicators for hospital burn care: a scoping review

BMC Health Services Research
Background Burn treatments are complex, and for this reason, a specialised multidisciplinary approach is recommended. Evaluating the quality of care provided to acute burn patients through quality indicators makes it possible to develop and implement ...
Denise R. Rabelo Suzuki, Levy Aniceto Santana, Juliana Elvira H. Guerra Ávila, Fábio Ferreira Amorim, Guilherme Pacheco Modesto, Leila Bernarda Donato Gottems, Vinicius Maldaner   +6 more
doaj   +1 more source

Quality Indicators for Transition from Pediatric to Adult Care for Youth With Chronic Conditions: Proposal for an Online Modified Delphi Study

JMIR Research Protocols
BackgroundThe transition from pediatric to adult care poses a significant health system–level challenge impeding the delivery of quality health services for youth with chronic health conditions.
Alene Toulany, Dmitry Khodyakov, Sarah Mooney, Lisa Stromquist, Katherine Bailey, Claire EH Barber, Michelle Batthish, Kristin Cleverley, Gina Dimitropoulos, Jan Willem Gorter, Danijela Grahovac, Ruth Grimes, Beverly Guttman, Michèle L Hébert, Tomisin John, Lisha Lo, Dorothy Luong, Laura MacGregor, Geetha Mukerji, Jacklynn Pidduck, Vjura Senthilnathan, Rayzel Shulman, Patricia Trbovich, Sarah EP Munce   +23 more
doaj   +1 more source