Results 141 to 150 of about 353,246 (310)

The year of transparency: measuring quality of cardiac care

, 2015
The assessment of quality of care is becoming increasingly important in healthcare, both globally and in the Netherlands. The Dutch Minister of Health declared 2015 to be the year of transparency, thereby aiming to improve quality of care by transparent ...
Bruijne, M.C. de, de Bruijne, M.C., B.A.J.M. de Mol, E. Wierda, Mol, B.A.J.M. de, D.C. D.C.Eindhoven, M.C. de Bruijne, D.C. Eindhoven, de Mol, B. A. J. M., Borleffs, C.J.W., de Bruijne, M. C., Umans, V. A. W. M., C.J.W. Borleffs, Schalij, M. J., De Mol, B.A.J.M., B.A.J.M. Mol, M.J. Schalij, Borleffs, C. J. W., Schalij, M.J., Wierda, E., Eindhoven, D.C., Umans, V.A.W.M., Eindhoven, D. C., G. Amoroso, V.A.W.M. Umans, Amoroso, G., M.C. Bruijne   +26 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Performance indicators for primary care management in the NHS [PDF]

There is increased emphasis on the measurement of performance in the NHS. Following the White Paper, additional high level indicators for measuring primary care performance at Health Authority level have been proposed by the NHS Executive.
Hugh Gravelle, Antonio Giuffrida, Martin Rowland   +2 more
core  

Quality standards for diabetes care toolkit 2014 [PDF]

, 2014
Provides resources and information to support service planning and delivery regarding diabetes care. Introduction Diabetes mellitus is a long term complex metabolic disorder characterised by high levels of blood glucose and caused by defects in insulin ...

core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Factors associated with the performance and achieving goals of specialized periodontal procedures in Brazilian dental specialties centers

BMC Health Services Research
Background The Brazilian Dental Specialty Centers (CEO, in Portuguese) represent the strategy of the National Oral Health Policy to provide secondary-level dental care. They offer more complex procedures, such as the treatment of periodontitis.
Raíres Chaves da Silva Rodrigues, Yuri Wanderley Cavalcanti, Edson Hilan Gomes de Lucena   +2 more
doaj   +1 more source

Developing a Service Quality Index System for AI Health Care Chatbots: Mixed Methods Study

Journal of Medical Internet Research
BackgroundArtificial intelligence (AI) health care chatbots are gaining widespread adoption worldwide. It is imperative to understand the service quality of AI health care chatbots.
Yu Gu, Xinyi Wang
doaj   +1 more source

Quality in cancer care: nurse sensitive indicators for ambulatory chemotherapy

, 2011
This project, commissioned by the National Cancer Action Team, developed and pilotted a suite of nurse sensitive indicators for ambulatory chemotherapy that contributed to the effective monitoring of these services.
Corner, J., Finnegan-John, Jennifer, Armes, Jo, Richardson, Alison, Wagland, Richard, Griffiths, Peter   +5 more
core