Results 131 to 140 of about 353,246 (310)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Quality indicators for hospital burn care: a scoping review

BMC Health Services Research
Background Burn treatments are complex, and for this reason, a specialised multidisciplinary approach is recommended. Evaluating the quality of care provided to acute burn patients through quality indicators makes it possible to develop and implement ...
Denise R. Rabelo Suzuki, Levy Aniceto Santana, Juliana Elvira H. Guerra Ávila, Fábio Ferreira Amorim, Guilherme Pacheco Modesto, Leila Bernarda Donato Gottems, Vinicius Maldaner   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

OECD Health Care Quality Indicators Project

, 2010
The OECD Health Care Quality Indicators Project (HCQI) builds on initial work by the Commonwealth Fund and Nordic Council of Ministers. The long-term goal is to develop and implement a set of quality indicators at the international level that could ultimately be used to produce benchmarks for countries.
Stevanovic, Vladimir, Garcia-Armesto, Sandra, Brownwood, Ian, Wei, Lihan, Fujisawa, Rie, Klazinga, Niek   +5 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evaluation of hybrid stroke quality indicators by integrating NIHSS and claims data for improved outcome prediction

Scientific Reports
Accurately measuring the quality of stroke care based on claims data alone is challenging. Traditional outcome metrics, e.g. mortality rates, do not capture the effectiveness of critical stroke care processes.
Thomas Datzmann, Caroline Lang, Falko Tesch, Melissa Spoden, Patrik Dröge, Franz Ehm, Ekkehard Schuler, Christos Krogias, Christian Günster, Jochen Schmitt, Christoph Gumbinger, Jessica Barlinn   +11 more
doaj   +1 more source

Do We Want to Measure the Quality of Care for Vulnerable Older People? The ACOVE Approach. Syracuse Seminar on Aging. [PDF]

There's limited information available about measuring the quality of medical care that is targeted to the needs of older patients. And there's very limited pressure on the system to provide high quality geriatric care. Why is that?
Neil S. Wenger
core  

Quality indicators for community care for older people: A systematic review

, 2018
Background Health care systems that succeed in preventing long term care and hospital admissions of frail older people may substantially save on their public spending. The key might be found in high-quality care in the community. Quality Indicators (QIs)
Liza van Eenoo, van Hout, Hein P. J., Vetrano, Davide L., Davide L. Vetrano, Anja Declercq, Vetrano, Davide L.,, van der Roest, Henriëtte G., van Eenoo, Liza, Smaardijk, Veerle R., Veerle R. Smaardijk, Henriëtte G. van der Roest, Declercq, Anja, Van Hout, Hein P.J., Onder, Graziano, Hein P. J. van Hout, Joling, Karlijn J., Karlijn J. Joling, Graziano Onder   +17 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source