Results 111 to 120 of about 353,246 (310)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Integral indicators of the quality of medical care – the way to build a high-quality health care system of Ukraine and the implementation of the best global practices for evaluating the effectiveness of health care technologies

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. About 60% of deaths from treatable conditions are caused by poor health care, while the remaining deaths result from failure to use the health care system. High-quality health systems can prevent 2.5 million deaths from cardiovascular disease,
Hladkykh F.V.
doaj   +1 more source

Cost and results of information systems for health and poverty indicators in the United Republic of Tanzania. [PDF]

, 2005
To examine the costs of complementary information generation activities in a resource-constrained setting and compare the costs and outputs of information subsystems that generate the statistics on poverty, health and survival required for monitoring ...
Boerma, Ties, Yusuf Hemed, Vanessa Rommelmann, Rommelmann, Vanessa, Philip W. Setel, David Whiting, Whiting, David, Setel, Philip W, Ties Boerma, Hemed, Yusuf, Mponezya, Hamisi, Gustavo Angeles, Angeles, Gustavo, Setel, Philip W., Hamisi Mponezya   +14 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A new set of quality indicators for palliative care: process and results of the development trajectory

, 2011
CONTEXT: In some countries (the United States in particular), quality indicators for palliative care have already been developed. However, these quality indicators often cover one specific setting or target group, for example, palliative cancer care or ...
Hella E. Belarbi, Francke, A.L., Claessen, Susanne JJ, Deliens, L., Belarbi, H.E., Belarbi, Hella E, Anneke L. Francke, Claessen, S.J.J., Pasman, H.R.W., Pasman, H Roeline W, van der Putten, Marianne JA, Deliens, Luc, van der Putten, M.J.A., H. Roeline W. Pasman, Luc Deliens, Susanne J.J. Claessen, Marianne J.A. van der Putten, Francke, Anneke L, Putten, M.J.A. van der   +18 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Quality Indicators for Physical and Behavioral Health Care Integration [PDF]

JAMA, 2015
Matthew L, Goldman, Brigitta, Spaeth-Rublee, Harold Alan, Pincus   +2 more
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source