Results 91 to 100 of about 180,214 (308)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Monitoring Global Water and Sanitation [PDF]
, 2013 The process of determining outputs and outcomes plays a key role in the setting of global targets, in defining national sector policy and strategic plans and in ensuring a continuous, safe supply of affordable water.
Norman, Rachel
core
, 2011 There are few indicator systems available for monitoring and assessing the environmental quality of large-scale regions. We constructed an indicator system for integrated assessment of the environmental quality of the Dianchi Basin. First, the definition
Rui Jia Yuan +3 more
core +1 more source
A novel simultaneous monitoring method for surface roughness and tool wear in milling process
Scientific ReportsQuality prediction and condition monitoring are crucial for realizing zero-defect intelligent manufacturing. Surface roughness is an important technical indicator to measure the surface quality of parts.
Ruilin Liu, Wenwen Tian
doaj +1 more source
SUBSYSTEM FOR MONITORING ATMOSPHERIC AIR QUALITY IN THE CYBER-PHYSICAL SYSTEM "SMART CITY"
Компютерні системи та інформаційні технологіїThe task of designing and developing a cyber-physical system "Smart City" is currently relevant for Ukraine. This study is devoted to the development of a method and subsystem for monitoring atmospheric air quality in the cyber-physical system "Smart ...
Tetiana HOVORUSHCHENKO +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Multiple Indication of Water Quality Monitoring System Using IoT
International Journal for Research in Applied Science and Engineering TechnologyThe growing population of humans, environmental degradation and climate change patterns have made clean water access more vital than ever. Maintaining water quality, especially for drinking, is crucial for public health. Conventional monitoring systems, though, are challenged in terms of data security, energy efficiency, and communication reliability ...
openaire +1 more source