Results 111 to 120 of about 180,214 (308)

Optimization of Regional Water Quality Monitoring Strategies

, 1987
A conceptual framework is presented for optimizing the operation of regional monitoring networks which assist water quality management. The primary objective of the studied network is to determine the annual nutrient load carried into a lake by its ...
J. Pintér, L. Somlyódy
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Indicators for measuring satisfaction towards design quality of buildings

, 2016
Design quality is an important component in measuring satisfaction towards total product quality (TPQ) of buildings, the product of construction projects.
M.F, Abu Bakar, Suratkon, Azeanita, S.Y, Lim, Jusoh, Safuan, Chan, Chee Ming, Z.J, Tan, H, Sutimin   +6 more
core   +1 more source

A Biological Sensor System Using Computer Vision for Water Quality Monitoring

IEEE Access, 2018
Water pollution has seriously threatened our life, so an effective water quality monitoring mechanism is the most important part of water quality management.
Fei Yuan, Yifan Huang, Xin Chen, En Cheng   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

SNIFFER WFD119: Enhancement of the River Invertebrate Classification Tool (RICT) [PDF]

, 2011
EXECUTIVE SUMMARY Project funders/partners: Environment Agency (EA), Northern Ireland Environment Agency (NIEA), Scotland & Northern Ireland Forum for Environmental Research (SNIFFER), Scottish Environment Protection Agency (SEPA) Background to ...
Scarlett, P.M., Dunbar, M., Clarke, Ralph T., Murphy, J.F., Davy-Bowker, John, Laize, C.   +5 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Smart Packaging System with Betalains and Rosemary Essential Oil to Extend Food Shelf Life and Monitor Quality During Storage

Polysaccharides
Smart packaging is an alternative that may not only replace plastic containers, but also enable food quality monitoring. In this study, an innovative packaging system was developed using a starch-chitosan polymer matrix, infused with rosemary essential ...
Noemi Takebayashi-Caballero, Carlos Regalado-González, Aldo Amaro Reyes, Silvia Lorena Amaya-Llano, José Ángel Granados-Arvizu, Genoveva Hernández Padrón, Víctor Castaño-Meneses, Monserrat Escamilla-García   +7 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Towards an ecological index for tropical soil quality based on soil macrofauna Em busca de um índice ecológico para a qualidade de solo tropical com base na macrofauna edáfica

, 2009
The objective of this work was to construct a simple index based on the presence/absence of different groups of soil macrofauna to determine the ecological quality of soils.
de Jong, B., Violette Geissen, Susana Ochoa-Gaona, Jong, B., de, Ben de Jong, Esperanza Huerta, Christian Kampichler, Geissen, V., Hernández-Daumás, S., Salvador Hernández-Daumás, Huerta, E., Kampichler, C., Ochoa-Gaona, S.   +12 more
core   +1 more source