Results 101 to 110 of about 24,703,824 (298)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Water Quality Monitoring and Assessment
, 2019 July 1, 2019Executive summary -- Introduction -- Kansas Water Resources -- Surface waters -- Streams and springs -- Lakes and reservoirs -- Wetlands -- Groundwater -- Status of Kansas water quality monitoring programs -- Allocation of duties -- Overview ...
Kansas Department of Health and Environment
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The American Journal of Management and Economics InnovationsCredit-modular education and micro-credentials are reshaping higher education through flexibility, mobility and lifelong learning. Despite extensive international policy development, evidence shows persistent gaps between quality assurance policy prescriptions and institutional implementation.
openaire +1 more source
Water Science and Technology, 1983 The actual detection of viruses or the use of an indicator system or systems to assess the presence of pathogenic viruses in contaminated environments is essential for the protection of human health. Herein are considered the possible surrogate relationships between pathogenic viruses and bacterial indicators of fecal pollution in the diverse ...
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Irish Maternity Indicator System National Report 2018
, 2019 This Irish Maternity Indicator System (IMIS) Interim Report shows data from 19 maternity hospitals/units from January through December 2018. It encompasses 33 multidisciplinary metrics across a range of domains, including demographics, deliveries ...
Office of the National Women and Infants Health Programme (NWIHP) +2 more
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Feasibility and reliability of a quality indicator system for an ambulatory dispensing service
Background: For a medication dispensing service to function with quality, continuous evaluation is required, which is why it is necessary to have reliable measurement tools that make it possible. Quality indicators can serve as tools for managing quality,
Liliana Barajas Esparza +10 more
core +1 more source
Place of indicative measurements in the atmospheric air quality monitoring system
Ecological Sciences, 2020 N. Sukha, L. Grygorieva
openaire +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Indicator quality for multidisciplinary systems
, 1999 In January 1998, a project studying the Unification of Indicator Quality for Assessment of Impact of Multidisciplinary Systems (UNIQUAIMS) began at IACR-Rothamsted.
Riley, J.
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