Results 41 to 50 of about 860,910 (266)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Software derivation requirements from improved business processes model: an experience at an academic office

GEPROS: Gestão da Produção, Operações e Sistemas, 2018
This paper presents a work of analysis and improvement of the students’ requisitions process in the academic registrar department of a federal teaching institution, using process modeling in BPMN notation, quality tools and derivation technique of ...
Amanda Gomes de Moura, Aline Pires Vieira de Vasconcelos, Alline Sardinha Cordeiro Morais, Rafael Leite de Freitas, Simone Vasconcelos Silva, Yuri Servedio   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Comparative Analysis of Pharmacopoeial Requirements for the Quality of Metoclopramide Medicinal Products

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Metoclopramide is a medicinal product widely used as an antiemetic. The pharmaceutical industry applies metoclopramide in the form of base or hydrochloride monohydrate.
L. I. Panova, L. Izganina, A. S. Vorozheykin, O. N. Zaitseva   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Engineering Safety- and Security-Related Quality Requirements

Technical Transactions, 2019
Safety- and security-related problems for software intensive systems are often due to poor or missing relevant engineering requirements. Although there is nothing really new in our presentation, specified problems and methods are well worth revisiting ...
Stojek Małgorzata
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Measuring. Monitoring. Management. Control

Измерение, мониторинг, управление, контроль
Background. Due to the increased interest in the use of oxide coatings in various industries, including medicine and electronics, it is necessary to systematize the known requirements for the quality parameters and operational properties of microarc ...
A.A. Maksov, E.A. Pecherskaya, P.E. Golubkov, O.A. Melnikov, B.V. Chuvykin, S.A. Poteshkin   +5 more
doaj   +1 more source

QUALITY PRODUCTS: PROBLEMS AND SOLUTIONS

Мир новой экономики, 2018
The article is devoted to the problems of improving the quality of products. Focused on integrated management of product quality and production efficiency. Studied foreign experience in Standardization(England, Germany, the United States, France, Japan),
LYUDMILA MIKHAILOVNA Kupriyanova
doaj