Results 51 to 60 of about 860,910 (266)
On the Distinction of Functional and Quality Requirements in Practice [PDF]
, 2016 Requirements are often divided into functional requirements (FRs) and quality requirements (QRs). However, we still have little knowledge about to which extent this distinction makes sense from a practical perspective. In this paper, we report on a survey we conducted with 103 practitioners to explore whether and, if so, why they handle requirements ...
Jonas Eckhardt +2 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Оценка и совершенствование системы контроля качества аудиторских услуг в Латвии
Фінансово-кредитна діяльність: проблеми теорії та практики, 2014 Аудиторская деятельность является одной из отраслей сферы услуг и не может развиваться независимо от основных тенденций в этой области. Стратегическое направление развития аудита – создание международного рынка аудиторских услуг с унифицированными ...
Л. М. Веровская
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Schema Understandability: A Comprehensive Empirical Study of Requirements Metrics
InformationEnsuring high-quality data warehouses is crucial for organizations, as they provide the reliable information needed for informed decision-making. While various methodologies emphasize the importance of requirements, conceptual, logical, and physical ...
Tanu Singh +3 more
doaj +1 more source
Quality Assurance Requirements at Takreet University : Analytical Study
المجلة العربية لضمان جودة التعليم الجامعي, 2013 : The research attempts to explain the concepts of total quality management and the role of the requirements in Tikrit University as a study. the sample of the research the head of department in human and senitific.
Naji Mahmood, Yaseen Jasem
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Studying Customer Satisfaction of Mashhad Airport Customs Based on Kano and Servqual Models [PDF]
International Journal of Management, Accounting and Economics, 2017 Over the past two decades, developed countries were shadowed by moving toward service-based economics, which is recently affecting developing countries.
Abbas Sharifipour +3 more
doaj