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Biometrics, 1955
Fisher (1954) has recently discussed the various transformations of probability used in the analysis of binomial data, and in that paper a full account of the statistical theory is given. While the assumption is often made that a distribution of thresholds must be postulated before efficient analysis may be made of binomial data (Finney, 1952a), Fisher
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Fisher (1954) has recently discussed the various transformations of probability used in the analysis of binomial data, and in that paper a full account of the statistical theory is given. While the assumption is often made that a distribution of thresholds must be postulated before efficient analysis may be made of binomial data (Finney, 1952a), Fisher
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Presynaptic facilitation: Quantal analysis and simulations
Neurocomputing, 1999Abstract The time-course of quantal neurosecretion indicated asynchrony in releases of presynaptic vesicles (quanta) in response to a stimulus. This was interpreted as reflecting the sequential release of vesicles from a single release site. We performed Monte-Carlo simulation of facilitated neurosecretion based upon the hypothesis that release sites
Maria Bykhovskaia +2 more
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Analysis of Quantal Response Assays with Dosage Errors
Biometrics, 1967This paper is conicerned with the problem of estimating the parameters of a tolerance distribution when the dose is subject to error of administration, and when observation is limited to the quantal, or all-or-lnone, respolise. The case when the errors in dose follow the Poisson law with known mean equal to the nominal dose is considered as a numerical
K M, Patwary, K D, Haley
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Quantal analysis using maximum entropy noise deconvolution
Journal of Neuroscience Methods, 1992When applying quantal analysis to synaptic transmission it is often unclear how much of the measured postsynaptic signal fluctuation arises from random sampling and noise rather than from the probabilistic transmitter release process. Unconstrained noise deconvolution methods do not overcome this because they tend to overfit the data, often giving a ...
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The Angular Transformation in Quantal Analysis
Biometrics, 1953The angular transformation may be used in two ways in the analysis of quantal data. Transformation of the observed response (Eisenhart, 1947) leads to a quick noniterative but approximate solution. If the expected response is transformed, an exact iterative maximum likelihood solution is available.
P. J. Claringbold +2 more
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Quantal Response Analysis for a Mixture of Populations
Biometrics, 1972SUMMARY This paper is concerned with the biological assay of a mixture of populations which cannot be differentiated on the basis of their external characteristics. It is shown that the overall dosage-response relation may be expressed in terms of the corresponding relations for the separate populations and of the proportion of each present in the ...
J R, Ashford, P J, Walker
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Generalized analysis of quantal dose-response curves
Computers and Biomedical Research, 1973Abstract Statistical advances now have broadened the scope of quantal dose-response analysis. Currently used probit and logit techniques suffer from two drawbacks, of which their inability to handle 0% and 100% responses is particularly troublesome. As a consequence, observations must be bunched into dose groups.
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Making quantal analysis easier and more accurate
Journal of Neuroscience Methods, 1997Problems inherent in applying quantal analysis to synapses are discussed. These include the dispersion in time of the evoked quantal releases and the skew to the right in the distribution of the sizes of the spontaneous miniature potentials. To circumvent some of the problems, quantal analysis was performed at the neuromuscular junction by dividing ...
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On Conjoint Analysis and Quantal Choice Models
The Journal of Business, 1980Conjoint analysis (or trade-off analysis) has become increasingly used in marketing. Essentially, the techniques attempt to parse the appeals of a product or concept into a set of factors, assign utility values to the separate levels of each factor, and finally, under the assumption of separability, determine the utility value of any product or concept
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Quantal Analysis of Hippocampal Long-Term Potentiation
Reviews in the Neurosciences, 1994Long-term potentiation (LTP) is a lasting (hours, days) increase in electrical responses after brief (seconds) high-frequency activation of monosynaptic pathways. It represents a popular model to study mechanisms of learning and memory. There is a general agreement on mechanisms of LTP induction, at least for LTP in hippocampal area CA1.
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