Results 11 to 20 of about 63 (58)
Merging Continuous Flow Technology, Photochemistry and Biocatalysis to Streamline Steroid Synthesis
Advanced Synthesis &Catalysis, Volume 365, Issue 23, Page 4024-4048, December 5, 2023., 2023 Abstract Since their structural elucidation in 1935, the introduction and substitution of functional groups and the modification of the steroidal scaffolds have been a fertile ground of research for synthetic and medicinal chemists. The discovery of steroids with hormonal and pharmacological activity has stimulated tremendous efforts to the development
Elena Tomarelli +3 more
wiley +1 more source
Transcription factor c‐Rel mediates communication between commensal bacteria and mucosal lymphocytes
Journal of Leukocyte Biology, Volume 111, Issue 5, Page 1001-1007, May 2022., 2022 Graphical Abstract The transcription factor c‐Rel regulates intestinal homeostasis and protects against pathogen colonization; c‐Rel‐deficient mice display defective IgA production in the intestine. Abstract The NF‐κB transcription factor c‐Rel plays a crucial role in promoting and regulating immune responses and inflammation.
Maik Luu +8 more
wiley +1 more source
Aging Cell, Volume 21, Issue 4, April 2022., 2022 We demonstrated that acidic nanoparticles, after intracerebral injection into a α‐synuclein‐based mouse model of PD, attenuated PD‐related neurodegeneration and synucleinopathy by mechanisms involving a rescue of compromised lysosomes. This study demonstrated that strategies enhancing or restoring lysosomal‐mediated degradation thus appear as ...
Marie‐Laure Arotcarena +10 more
wiley +1 more source
Journal of Food Science, Volume 87, Issue 2, Page 808-818, February 2022., 2022 Abstract Proteolytic enzymes or fungi have long been identified as causing softening of pickled cucumbers. As the softening of cucumbers occurs mainly in the pasteurized state, this study considers the hypothesis that vinegar and the added spices could be responsible for this softening by studying polygalacturonase (endo‐/exo‐PG), pectinesterase (PE ...
Sabrina Scharf +3 more
wiley +1 more source
Journal of Ecology, Volume 110, Issue 1, Page 97-116, January 2022., 2022 In the BEF‐China experiment, metabolomics samples were collected from four different species and three organs (a). The metabolomes are species and organ specific (b), and the metabolome specificity is attributed to different chemical classes (c). Tree species diversity affects the metabolome composition (d), but more controlled interaction experiments ...
Alexander Weinhold +7 more
wiley +1 more source
Physiologia Plantarum, Volume 174, Issue 1, January/February 2022., 2022 Abstract The low bioavailability of nutrients, especially nitrogen (N) and phosphorus (P), is one of the most limiting factors for crop production. In this study, under N‐ and P‐free nutrient solution (−N−P), nodulating white lupin plants developed some nodules and analogous cluster root structures characterized by different morphological ...
Sara Buoso +8 more
wiley +1 more source
ESC Heart Failure, Volume 8, Issue 6, Page 4674-4684, December 2021., 2021 Abstract Aims Acute cellular rejection (ACR) following heart transplantation (HTX) is associated with long‐term graft loss and increased mortality. Disturbed mitochondrial bioenergetics have been identified as pathophysiological drivers in heart failure, but their role in ACR remains unclear.
Daniel Scheiber +15 more
wiley +1 more source
Journal of Chemistry, Volume 2021, Issue 1, 2021., 2021 Origanum genus is one of the most widely used herbs in folk medicine for its biological properties. The present investigation aims to characterize, for the first time, endemic Origanum grosii collected from the Taounate region, Morocco. This characterization was realized by determining the concentration of metals in different parts of the plant ...
H. El hassouni +6 more
wiley +1 more source
, 2023 This study was carried ou within the scope of valorizing non-timber forest products in the Democratic Republic of Congo. It focuses on understanding the importance, biochemical properties, and in vitro glycophagic activity of fruits from two Synsepalum ...
MENGA, Pisco +5 more
core +1 more source
Mcl‐1 targeting strategies unlock the proapoptotic potential of TRAIL in melanoma cells
Molecular Carcinogenesis, Volume 59, Issue 11, Page 1256-1268, November 2020., 2020 Abstract TNF‐related apoptosis‐inducing ligand (TRAIL) induces apoptosis selectively in cancer cells. For melanoma, the targeting of TRAIL signaling appears highly attractive, due to pronounced TRAIL receptor expression in tumor tissue. However, mechanisms of TRAIL resistance observed in melanoma cells may limit its clinical use.
Zina Sarif +3 more
wiley +1 more source