Results 21 to 26 of about 30 (26)

Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells

open access: yesSmall Methods, Volume 10, Issue 3, 9 February 2026.
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner   +7 more
wiley   +1 more source

Rod‐shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 16, 23 June, 2025.
Rod‐shaped particles outperform spherical particles of the same volume in preventing neutrophil infiltration to inflamed areas, both in vitro and in vivo. This therapeutic effectiveness is attributed to better cell targeting and decreased cell motility, resulting from the geometry‐driven phagocytosis and inhibited actin polymerization.
M. Valentina Guevara   +7 more
wiley   +1 more source

Nutritional Potential and Protective Effects of Colocassia esculenta Flowers Against 2,4‐Dinitrophenyl Hydrazine (DNPH) Induced Anemia Wistar Strain Rats

open access: yesFood Science &Nutrition, Volume 13, Issue 6, June 2025.
The nutritional properties of C. esculenta have been demonstrated. Consumption of C. esculenta reduces anemic disorder in Wistar rats. C. esclenta harvested in Dschang has the best anti‐anemic potential. ABSTRACT This study aimed to assess the nutritional value and effect of Colocasia esculenta flowers on induced anemia in Wistar rats.
Josée Rebecca Nombo   +6 more
wiley   +1 more source

Surface CD69‐Negative CD4 and CD8 Bone Marrow‐Resident Human Memory T Cells

open access: yesEuropean Journal of Immunology, Volume 55, Issue 5, May 2025.
Through the analysis of TCR repertoires, differential gene expression, and flow cytometry, we propose a mechanism in which surface CD69‐negative memory T cells reside in the bone marrow of healthy humans. Therefore, we challenge the notion of surface CD69‐positive T cells representing the only bona fide resident phenotype in the bone marrow.
Emilia Schneider Revueltas   +16 more
wiley   +1 more source

Molecular and functional in vivo characterisation of murine Dectin‐1 isoforms

open access: yesEuropean Journal of Immunology, Volume 54, Issue 11, November 2024.
Dectin‐1 is a C‐type lectin receptor for the innate sensing of fungi. This receptor exists in two major isoforms in mice differing in a stalk domain, which determines their degradative pathway. Here, we characterise the properties of the two isoforms in a cellular context and using a newly established in vivo model. Abstract Dectin‐1 is a C‐type lectin‐
Nadja Leinung   +3 more
wiley   +1 more source

Platinum Nanozyme Probes for Cellular Imaging by Electron Microscopy

open access: yesSmall Science, Volume 4, Issue 9, September 2024.
This study introduces a novel technique, exploiting platinum nanozyme probes, to improve the localization of specific cellular components via transmission electron microscopy. This approach represents a significant development with respect to traditional amplification systems in electron microscopy, offering advanced imaging capabilities for detailed ...
Elisa De Luca   +9 more
wiley   +1 more source

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