Results 81 to 90 of about 7,538,439 (269)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Evaluation of the fragility curve for steel structures with linked columns frame system under sequences of critical earthquakes

Discover Civil Engineering
Fragility curves as a powerful tool assess the possible damage to existing structures and estimate the probability of structural damage exceeding a given level of seismic damage for several levels of seismic ground motions.
Yaser Golestani, Elham Rajabi
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Quantitative spectroscopic analysis of and distance to SN1999em

, 2005
This work presents a detailed quantitative spectroscopic analysis of, and the determination of the distance to, the type II supernovae (SN) SN1999em with CMFGEN (Dessart & Hillier 2005a), based on spectrophotometric observations at eight dates up to 40 ...
Arnett, Baade, Baron, Baron, Burrows, Clayton, Crowther, D. J. Hillier, Dessart, Dessart, Eastman, Eastman, Ensman, Hamuy, Hauschildt, Hillier, Hillier, Hillier, Hirshi, Jeffery, Kirshner, L. Dessart, Leonard, MacFadyen, MacFadyen, Martins, Mitchell, Najarro, Prantzos, Schmidt, Utrobin, Woosley   +31 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Note on Buyers’ Behavior in Auctions with an Outside Option

Games, 2020
In this note I show that the equilibrium in cutoff strategies observed in auctions with a buy-it-now price may also arise in markets where objects are sold simultaneously by auctions and posted prices.
Alexander Maslov
doaj   +1 more source

Quantitative Analysis of the Italian National Scientific Qualification

, 2015
The Italian National Scientific Qualification (ASN) was introduced in 2010 as part of a major reform of the national university system. Under the new regulation, the scientific qualification for a specific role (associate or full professor) and field of ...
Marzolla, Moreno
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Fractional-order mathematical modeling of toxoplasmosis transmission dynamics with harmonic mean-type incidence rate

Scientific Reports
Mathematical modeling is an effective tool for understanding and predicting certain endemic diseases. Toxoplasmosis gondii (T. gondii) is an endemic disease that is transmitted to human by contact with infected cats. T. gondii can cause a lot of diseases
Muhammad Asif, Ioan-Lucian Popa, Emad A. A. Ismail, Fuad A. Awwad, Mosab Alqurashi, Umar Ishtiaq   +5 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source