Results 71 to 80 of about 7,422,915 (294)
A new chapter for RCSB Protein Data Bank Molecule of the Month in 2025
Structural DynamicsThe online Molecule of the Month series authored by David S. Goodsell and published by the Research Collaboratory for Structural Biology Protein Data Bank at PDB101.RCSB.org has highlighted stories about the biomolecular structures driving fundamental ...
Janet Iwasa +3 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Navigating the paradigm shift of sex inclusive preclinical research and lessons learnt
Communications BiologyAfter thirty years of research highlighting the risk of the sex bias in preclinical research, we now have tangible change happening in the research landscape with a rapid increase in the proportions of studies including female and male subjects.
Natasha A. Karp
doaj +1 more source
, 2019 The intention of this chapter is to demystify quantitative research and give readers clear, straightforward information about collecting and analysing quantitative data. It does this by clarifying key concepts and terms and illustrating these with examples taken from the author’s own research and other investigations.
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Measuring Social Economy in Public Statistics: Introduction to the Polish Experience
Social Entrepreneurship ReviewThis article presents the objectives, scope, and evolution of the research on social economy conducted by the Research Centre for Social Economy at the Statistical Office in Krakow (Statistics Poland).
Agnieszka Pacut
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Stochastic Gates for Covariate Selection in Population Pharmacokinetics Modeling
CPT: Pharmacometrics & Systems PharmacologyCovariate selection in population pharmacokinetics modeling is essential for understanding interindividual variability in drug response and optimizing dosing.
Marija Kekic +10 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source